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. 2023 Dec 11;15(12):2403.
doi: 10.3390/v15122403.

High Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Infection among the Dog Population in Thailand

Keita Ishijima  1 , Thanmaporn Phichitraslip  2 , Nattakarn Naimon  2 , Preeyaporn Ploypichai  2 , Benyapa Kriebkajon  2 , Torntun Chinarak  2 , Jirasin Sridaphan  2 , Anamika Kritiyakan  2 , Noppadol Prasertsincharoen  2 , Sathaporn Jittapalapong  2 , Kanate Tangcham  3 , Worawut Rerkamnuaychoke  4 , Yudai Kuroda  1 , Masakatsu Taira  1 , Kango Tatemoto  1 , Eunsil Park  1 , Milagros Virhuez-Mendoza  1 , Yusuke Inoue  1   5 , Michiko Harada  1   5 , Tsukasa Yamamoto  1   5 , Ayano Nishino  1   5 , Aya Matsuu  1 , Ken Maeda  1   5
Affiliations

High Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Infection among the Dog Population in Thailand

Keita Ishijima et al. Viruses. .

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonotic disease caused by the SFTS virus (SFTSV). In Thailand, three human cases of SFTS were reported in 2019 and 2020, but there was no report of SFTSV infection in animals. Our study revealed that at least 16.6% of dogs in Thailand were seropositive for SFTSV infection, and the SFTSV-positive dogs were found in several districts in Thailand. Additionally, more than 70% of the serum samples collected at one shelter possessed virus-neutralization antibodies against SFTSV and the near-complete genome sequences of the SFTSV were determined from one dog in the shelter. The dog SFTSV was genetically close to those from Thailand and Chinese patients and belonged to genotype J3. These results indicated that SFTSV has already spread among animals in Thailand.

Keywords: ELISA; RT-PCR; Thailand; companion animal; dogs; severe fever with thrombocytopenia syndrome; zoonosis.

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Conflict of interest statement

The authors declare no conflict of interest in association with the present study.

Figures

Figure 1
Figure 1
Phylogenetic analysis by the maximum likelihood method based on the nucleotide sequences of the small (A), medium (B), and large (C) segments. The Guertu virus that was used as an outgroup is not shown. The black circle indicates the nodes. The bold text indicates the virus strain detected in this study. The number at each branch indicates the Shimodaira–Hasegawa approximate likelihood ratio test (SH-aLRT) value (%)/ultrafast bootstrap (UFBoot) value (%). These values are shown when SH-aLRT value is ≥80% and UFBoot value is ≥95%.
Figure 1
Figure 1
Phylogenetic analysis by the maximum likelihood method based on the nucleotide sequences of the small (A), medium (B), and large (C) segments. The Guertu virus that was used as an outgroup is not shown. The black circle indicates the nodes. The bold text indicates the virus strain detected in this study. The number at each branch indicates the Shimodaira–Hasegawa approximate likelihood ratio test (SH-aLRT) value (%)/ultrafast bootstrap (UFBoot) value (%). These values are shown when SH-aLRT value is ≥80% and UFBoot value is ≥95%.
See this image and copyright information in PMC

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