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. 2024 Apr;262(4):1271-1279.
doi: 10.1007/s00417-023-06349-x. Epub 2023 Dec 23.

The effect of uneventful cataract surgery on Schlemm's canal and the trabecular meshwork in cases with pseudoexfoliation

Oksan Alpogan  1 , Hatice Tekcan  2 , Serhat Imamoglu  2 , Yucel Ozturk  2 , Ruveyde Bolac  2
Affiliations

The effect of uneventful cataract surgery on Schlemm's canal and the trabecular meshwork in cases with pseudoexfoliation

Oksan Alpogan et al. Graefes Arch Clin Exp Ophthalmol. 2024 Apr.

Abstract

Purpose: To evaluate the effect of uneventful cataract surgery on Schlemm's canal (SC) and the trabecular meshwork (TM) in cases with pseudoexfoliation (PX).

Methods: In this prospective study, 37 PX and 37 normal eyes, who underwent cataract surgery, were included. The PX group was further divided into two subgroups: PX syndrome (PXS) and PX glaucoma (PXG). Preoperative complete ophthalmologic examination, anterior segment (AS) imaging using a Scheimpflug camera, and measurements of SC length and area and TM thickness and length using AS optical coherence tomography (AS-OCT) were performed in all cases. All measurements were repeated at the first and third months after surgery.

Results: Preoperative intraocular pressure (IOP), AS parameters, SC, and TM values showed no significant differences between the groups (p > 0.05). After surgery, there was a significant increase in AS parameter values and a significant decrease in IOP values in both the PX and control groups (p < 0.05). The nasal and temporal SC area showed a significant increase in the PX group after surgery (p = 0.007, p = 0.003, respectively). In the subgroup analysis, the only significant change in the nasal and temporal SC area was in the PXS group (p = 0.006, p = 0.003, respectively).

Conclusion: Cataract surgery resulted in an increase in the SC area in patients with PXS. This increase may be due to multiple mechanisms including the IOP-lowering effect of cataract removal, change in AS, and removal of intraocular PX material after surgery.

Keywords: Cataract surgery; Glaucoma; Pseudoexfoliation; Schlemm’s canal; Trabecular meshwork.

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References

    1. Kwon YH, Fingert JH, Kuehn MH et al (2009) Primary open-angle glaucoma. N Engl J Med 360:1113–1124. https://doi.org/10.1056/NEJMra0804630 - DOI - PubMed - PMC
    1. Stamer WD, Braakman ST, Zhou EH, Ethier CR, Fredberg JJ, Overby DR, Johnson M (2015) Biomechanics of Schlemm’s canal endothelium and intraocular pressure reduction. Prog Retin Eye Res 44:86–98. https://doi.org/10.1016/j.preteyeres.2014.08.002 - DOI - PubMed
    1. Schlötzer-Schrehardt U, Naumann GO (1995) Trabecular meshwork in pseudoexfoliation syndrome with and without open-angle glaucoma. A morphometric, ultrastructural study. Invest Ophthalmol Vis Sci 36:1750–1764 - PubMed
    1. Asrani S, Sarunic M, Santiago C, Izatt J (2008) Detailed visualization of the anterior segment using fourier-domain optical coherence tomography. Arch Ophthalmol 126:765–771. https://doi.org/10.1001/archopht.126.6.765 - DOI - PubMed - PMC
    1. Kagemann L, Wollstein G, Ishikawa H, Bilonick RA, Brennen PM, Folio LS, Gabriele ML, Schuman JS (2010) Identification and assessment of Schlemm’s canal by spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci 51:4054–4059. https://doi.org/10.1167/iovs.09-4559 - DOI - PubMed - PMC

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