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Review
. 2024 Feb;11(2):e117-e124.
doi: 10.1016/S2352-3018(23)00264-3. Epub 2023 Dec 20.

Prophylactic HIV-1 vaccine trials: past, present, and future

Joseph P Nkolola  1 , Dan H Barouch  2
Affiliations
Review

Prophylactic HIV-1 vaccine trials: past, present, and future

Joseph P Nkolola et al. Lancet HIV. 2024 Feb.

Abstract

An effective HIV-1 vaccine is a global health priority but has remained elusive for more than 40 years. Key scientific hurdles that have hampered vaccine development are the unprecedented genetic variability of the virus, the rapid establishment of persistent viral latency, and the challenges associated with induction of broadly neutralising antibodies. Clinical trials have been instrumental in evaluating scientific concepts and testing vaccine strategies. This Review discusses lessons learned from clinical trials of HIV-1 vaccines, current technologies that are being explored, and future considerations in the development of a safe and effective HIV-1 vaccine.

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Conflict of interest statement

Declaration of interests DHB is a co-inventor on HIV-1 vaccine patents that have been licensed. JPN declares no competing interests.

Figures

Figure:
Figure:. Emerging HIV-1 vaccine concepts in early phase clinical testing
Env=surface envelope. FP=fusion peptide.
See this image and copyright information in PMC

Comment in

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