Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data

doi:10.1016/j.maturitas.2023.107902

Meta-Analysis

. 2024 Feb:180:107902.

doi: 10.1016/j.maturitas.2023.107902. Epub 2023 Dec 15.

Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data

Charlotte Beaudart¹, Noémie Tilquin², Pawel Abramowicz³, Fátima Baptista⁴, Dao Juan Peng⁵, Fabiana de Souza Orlandi⁶, Michael Drey⁷, Marta Dzhus⁸, Raquel Fábrega-Cuadros⁹, Julio Fernandez-Garrido¹⁰, Lucas Fornari Laurindo¹¹, Andrea-Ildiko Gasparik¹², Anton Geerinck¹³, Gyulnaz Emin¹⁴, Speranta Iacob¹⁵, Justina Kilaitė¹⁶, Prabal Kumar¹⁷, Shu-Chun Lee¹⁸, Vivian W Q Lou¹⁹, Marzieh Mahmoodi²⁰, Radmila Matijevic²¹, Mariia V Matveeva²², Blandine Merle²³, Beatriz Montero-Errasquín²⁴, Harjit Pal Bhattoa²⁵, Yuliya Safonova²⁶, Hilal Şimşek²⁷, Eva Topinkova²⁸, Maria Tsekoura²⁹, Tuğba Erdoğan³⁰, Jun-Il Yoo³¹, Ruby Yu³², Mickael Hiligsmann³³, Jean-Yves Reginster³⁴, Olivier Bruyère³⁴

Affiliations

¹ Departement of Biomedical Sciences, Namur Research Institute for Life Sciences (NARILIS), Faculty of Medicine, University of Namur, Namur, Belgium; WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium; Department of Health Services Research, University of Maastricht, Maastricht, the Netherlands. Electronic address: charlotte.beaudart@unamur.be.
² Department of Biomedical Sciences, Faculty of Health, Medicine, and Life Sciences (FHML), Maastricht University, Maastricht, the Netherlands.
³ Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, Bialystok, Poland.
⁴ Department of Sports and Health, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
⁵ Nursing Department, Affiliated Hospital of Zunyi Medical University, Dalian Road, Huichuan District, Zunyi, Guizhou, China.
⁶ Department of Gerontology, Federal University of São Carlos, Brazil.
⁷ Department of Medicine IV, LMU University Hospital, LMU Munich, Germany.
⁸ Bogomolets National Medical University, Department of Internal Medicine, Kyiv, Ukraine.
⁹ Department of Health Sciences, University of Jaén, Jaén, Spain.
¹⁰ Faculty of Nursing and Podiatry, University of Valencia, Valencia, Spain.
¹¹ Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, Brazil; Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília 17519-030, São Paulo, Brazil.
¹² Department of Public Health and Health Management, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania.
¹³ Departement of Biomedical Sciences, Namur Research Institute for Life Sciences (NARILIS), Faculty of Medicine, University of Namur, Namur, Belgium.
¹⁴ Yeni Yüzyıl University Gaziosmanpaşa Hospital, Physical Medicine and Rehabilitation Department, Istanbul, Turkey.
¹⁵ Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Fundeni Clinical Institute, Bucharest, Romania.
¹⁶ Clinic of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁷ Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka 576104, India.
¹⁸ School of Gerontology and Long-Term Care, College of Nursing, Taipei Medical University, Taiwan.
¹⁹ Sau Po Centre on Ageing, Department of Social Work & Social Administration, The University of Hong Kong, Hong Kong.
²⁰ Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
²¹ University of Novi Sad, Faculty of Medicine in Novi Sad, Serbia, Orthopaedic and Trauma Clinic, Novi Sad, Serbia.
²² Siberian State Medical University, Department of Pediatrics with Course of Enoccrinology, Department of Outpatient Therapy, Tomsk, Russian Federation.
²³ INSERM UMR 1033-Université de Lyon, 5 Place d'Arsonval, 69437 Lyon, France.
²⁴ Servicio de Geriatría, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
²⁵ Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Hungary.
²⁶ Department of Geriatrics, North Western State Medical University, named after I.I. Mechnikov, Russian Federation.
²⁷ Hilal Simsek: Department of Nutrition and Dietetics, Graduate School of Health Sciences, Ankara University, Ankara, Turkey.
²⁸ Department of Geriatric Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Health and Social Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic.
²⁹ Department of Physiotherapy, School of Health Rehabilitation Sciences, University of Patras, Rio, Greece.
³⁰ Internal Medicine and Geriatrics Clinic, Tekirdağ Dr. Ismail Fehmi Cumalıoğlu City Hospital, Tekirdağ, Turkey.
³¹ Department of Orthopaedic Surgery, Inha University Hospital, 27, Inhang-Ro, Jun-Gu, Incheon 22332, Republic of Korea.
³² CUHK Jockey Club Institute of Ageing, The Chinese University of Hong Kong, New Territories, Hong Kong.
³³ Department of Health Services Research, University of Maastricht, Maastricht, the Netherlands.
³⁴ WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.

PMID: 38142467
DOI: 10.1016/j.maturitas.2023.107902

Free article

Meta-Analysis

Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data

Charlotte Beaudart et al. Maturitas. 2024 Feb.

Free article

. 2024 Feb:180:107902.

doi: 10.1016/j.maturitas.2023.107902. Epub 2023 Dec 15.

Authors

Affiliations

¹ Departement of Biomedical Sciences, Namur Research Institute for Life Sciences (NARILIS), Faculty of Medicine, University of Namur, Namur, Belgium; WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium; Department of Health Services Research, University of Maastricht, Maastricht, the Netherlands. Electronic address: charlotte.beaudart@unamur.be.
² Department of Biomedical Sciences, Faculty of Health, Medicine, and Life Sciences (FHML), Maastricht University, Maastricht, the Netherlands.
³ Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, Bialystok, Poland.
⁴ Department of Sports and Health, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
⁵ Nursing Department, Affiliated Hospital of Zunyi Medical University, Dalian Road, Huichuan District, Zunyi, Guizhou, China.
⁶ Department of Gerontology, Federal University of São Carlos, Brazil.
⁷ Department of Medicine IV, LMU University Hospital, LMU Munich, Germany.
⁸ Bogomolets National Medical University, Department of Internal Medicine, Kyiv, Ukraine.
⁹ Department of Health Sciences, University of Jaén, Jaén, Spain.
¹⁰ Faculty of Nursing and Podiatry, University of Valencia, Valencia, Spain.
¹¹ Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, Brazil; Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília 17519-030, São Paulo, Brazil.
¹² Department of Public Health and Health Management, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania.
¹³ Departement of Biomedical Sciences, Namur Research Institute for Life Sciences (NARILIS), Faculty of Medicine, University of Namur, Namur, Belgium.
¹⁴ Yeni Yüzyıl University Gaziosmanpaşa Hospital, Physical Medicine and Rehabilitation Department, Istanbul, Turkey.
¹⁵ Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Fundeni Clinical Institute, Bucharest, Romania.
¹⁶ Clinic of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁷ Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka 576104, India.
¹⁸ School of Gerontology and Long-Term Care, College of Nursing, Taipei Medical University, Taiwan.
¹⁹ Sau Po Centre on Ageing, Department of Social Work & Social Administration, The University of Hong Kong, Hong Kong.
²⁰ Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
²¹ University of Novi Sad, Faculty of Medicine in Novi Sad, Serbia, Orthopaedic and Trauma Clinic, Novi Sad, Serbia.
²² Siberian State Medical University, Department of Pediatrics with Course of Enoccrinology, Department of Outpatient Therapy, Tomsk, Russian Federation.
²³ INSERM UMR 1033-Université de Lyon, 5 Place d'Arsonval, 69437 Lyon, France.
²⁴ Servicio de Geriatría, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
²⁵ Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Hungary.
²⁶ Department of Geriatrics, North Western State Medical University, named after I.I. Mechnikov, Russian Federation.
²⁷ Hilal Simsek: Department of Nutrition and Dietetics, Graduate School of Health Sciences, Ankara University, Ankara, Turkey.
²⁸ Department of Geriatric Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Health and Social Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic.
²⁹ Department of Physiotherapy, School of Health Rehabilitation Sciences, University of Patras, Rio, Greece.
³⁰ Internal Medicine and Geriatrics Clinic, Tekirdağ Dr. Ismail Fehmi Cumalıoğlu City Hospital, Tekirdağ, Turkey.
³¹ Department of Orthopaedic Surgery, Inha University Hospital, 27, Inhang-Ro, Jun-Gu, Incheon 22332, Republic of Korea.
³² CUHK Jockey Club Institute of Ageing, The Chinese University of Hong Kong, New Territories, Hong Kong.
³³ Department of Health Services Research, University of Maastricht, Maastricht, the Netherlands.
³⁴ WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.

PMID: 38142467
DOI: 10.1016/j.maturitas.2023.107902

Abstract

Age-related sarcopenia, resulting from a gradual loss in skeletal muscle mass and strength, is pivotal to the increased prevalence of functional limitation among the older adult community. The purpose of this meta-analysis of individual patient data is to investigate the difference in health-related quality of life between sarcopenic individuals and those without the condition using the Sarcopenia Quality of Life (SarQoL) questionnaire. A protocol was published on PROSPERO. Multiple databases and the grey literature were searched until March 2023 for studies reporting quality of life assessed with the SarQoL for patients with and without sarcopenia. Two researchers conducted the systematic review independently. A two-stage meta-analysis was performed. First, crude (mean difference) and adjusted (beta coefficient) effect sizes were calculated within each database; then, a random effect meta-analysis was applied to pool them. Heterogeneity was measured using the Q-test and I² value. Subgroup analyses were performed to investigate the source of potential heterogeneity. The strength of evidence of this association was assessed using GRADE. From the 413 studies identified, 32 were eventually included, of which 10 were unpublished data studies. Sarcopenic participants displayed significantly reduced health-related quality of life compared with non-sarcopenic individuals (mean difference = -12.32; 95 % CI = [-15.27; -9.37]). The model revealed significant heterogeneity. Subgroup analyses revealed a substantial impact of regions, clinical settings, and diagnostic criteria on the difference in health-related quality of life between sarcopenic and non-sarcopenic individuals. The level of evidence was moderate. This meta-analysis of individual patient data suggested that sarcopenia is associated with lower health-related quality of life measured with SarQoL.

Keywords: Health-related quality of life; Individual-patient data meta-analysis; SarQoL; Sarcopenia.

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Conflict of interest statement

Declaration of competing interest B.C., B.O., and R.J.Y. are shareholders of the SarQoL sprl. However, they never received any financial compensation for this role. The other authors declare they have no competing interest.

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Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data

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Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data

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