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. 2024 Jan;30(1):168-171.
doi: 10.3201/eid3001.230756.

Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09

Pavithra Daulagala, Samuel M S Cheng, Alex Chin, Leo L H Luk, Kathy Leung, Joseph T Wu, Leo L M Poon, Malik Peiris, Hui-Ling Yen

Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09

Pavithra Daulagala et al. Emerg Infect Dis. 2024 Jan.

Abstract

We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.

Keywords: clade 2.3.4.4.b; cross-reactive antibody response; influenza; influenza A(H1N1)pdm09; influenza A(H5N1); neuraminidase inhibition antibody; pandemic risk assessment; respiratory infections; viruses.

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Figures

Figure
Figure
Age-stratified HAI and NAI antibody responses to influenza A(H1N1)pdm09 (California/09) and A(H5N1) (Spoonbill/HK/22) viruses in serum samples collected from healthy adults in 2020 and 2009, Hong Kong, China. A, B) Results for serum samples of 63 healthy adults collected in 2020. C, D) Results for serum samples of 50 healthy adults collected in 2009. The assay detection limit was 1:10, and samples with antibody below the detection limit were assigned an arbitrary antibody titer of 5, which is used to calculate geometric mean titer. The HAI and NAI titers across different age groups were compared using Kruskal-Wallis test and Dunn’s multiple comparison test. HAI, hemagglutination inhibition; NAI, neuraminidase inhibition.
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