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Comment
. 2024 Jan 2;121(1):e2319797121.
doi: 10.1073/pnas.2319797121. Epub 2023 Dec 26.

Molecular chaos under the skin: Epigenetic reprogramming in hidradenitis suppurativa

Gagan Chhabra  1 , Nihal Ahmad  1   2
Affiliations
Comment

Molecular chaos under the skin: Epigenetic reprogramming in hidradenitis suppurativa

Gagan Chhabra et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Epigenetic reprogramming in human skin inflammatory disorder HS. Compared to healthy skin, HS lesional epidermis is surrounded by heterogenous basal stem/progenitor cells with a significantly increased number of PTTG1+, HELLS+, and COL17A1+ cells favoring the recruitment of HS-associated immune cells. Stem cells lose their identity and differentiate to favor the formation of an epidermal cyst. HS-specific S100A+ keratinocyte cells amplify immune responses. After early inflammatory signals, substantial chromatin remodeling occurs in the genomic landscape of basal keratinocytes causing transcriptional activation of HS-associated genes to further drive recurrent inflammatory insults. The figure was created using Biorender.
See this image and copyright information in PMC

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References

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