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Review
. 2023 Oct 26:28:76.
doi: 10.4103/jrms.jrms_216_23. eCollection 2023.

The denervation or activation of renal sympathetic nerve and renal blood flow

Fatemeh Kharazmi  1   2 , Hajaralsadat Hosseini-Dastgerdi  1   2 , Ali-Asghar Pourshanazari  2 , Mehdi Nematbakhsh  1   2
Affiliations
Review

The denervation or activation of renal sympathetic nerve and renal blood flow

Fatemeh Kharazmi et al. J Res Med Sci. .

Abstract

The denervation or activation of the sympathetic nerve in the kidney can affect renal hemodynamics. The sympathetic nervous system regulates the physiological functions of the kidneys. Stimulation of sympathetic efferent nerves affects various parameters related to renal hemodynamics, including sodium excretion, renin secretion, and renal blood flow (RBF). Hence, renal sympathetic fibers may also play an essential role in regulating systemic vascular resistance and controlling blood pressure. In the absence of renal nerves, the hemodynamics response to stimuli is negligible or absent. The effect of renal sympathetic denervation on RBF is dependent on several factors such as interspecies differences, the basic level of nerve activity in the vessels or local density of adrenergic receptor in the vascular bed. The role of renal denervation has been investigated therapeutically in hypertension and related disorders. Hence, the dynamic impact of renal nerves on RBF enables using RBF dynamic criteria as a marker for renal denervation therapy.

Keywords: Renal blood flow; renal sympathetic denervation; renal sympathetic nerve activity.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic image of the effect of increased renal sympathetic nerve activity on different parts of the kidney. RSNA = Renal sympathetic nerve activity
Figure 2
Figure 2
Schematic image of the connections between renal afferent sensory signaling and renal efferent sympathetic outflow on the kidney and other cardiovascular organs, which regulate blood pressure. Renal mechano and chemoreceptor reflexes, which are carried out by renal afferent nerves, regulate the activity of premotor neurons in the rostral ventrolateral medulla and paraventricular nucleus. CR = Renal chemoreceptors; DRG = Dorsal root ganglion; IML = Intermediolateral cell column; MR = Renal mechanoreceptors; NTS = Nucleus tractus solitarius; PVN = Paraventricular nucleus of the hypothalamus; RVLM = Rostral ventrolateral medulla; SFO = Subfornical organ
See this image and copyright information in PMC

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