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. 2023 Oct;200(4):396-416.
doi: 10.1667/rade-22-00004.1. Epub 2023 Sep 13.

Immune Dysfunction from Radiation Exposure

Brynn A Hollingsworth  1   2 , Jennifer T Aldrich  3 , Cullen M Case Jr  3 , Andrea L DiCarlo  1 , Corey M Hoffman  4 , Ann A Jakubowski  3 , Qian Liu  5 , Shannon G Loelius  4 , Mercy PrabhuDas  5 , Thomas A Winters  1 , David R Cassatt  1
Affiliations

Immune Dysfunction from Radiation Exposure

Brynn A Hollingsworth et al. Radiat Res. 2023 Oct.

Abstract

The hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune system may result in opportunistic infections and hemorrhage, which could lead to mortality. Inflammation triggered by tissue damage can also lead to additional local or widespread tissue damage. The immune system is responsible for tissue repair and restoration, which is made more challenging when it is in the process of self-recovery. Because of these challenges, the Radiation and Nuclear Countermeasures Program (RNCP) and the Basic Immunology Branch (BIB) under the Division of Allergy, Immunology, and Transplantation (DAIT) within the National Institute of Allergy and Infectious Diseases (NIAID), along with partners from the Biomedical Advanced Research and Development Authority (BARDA), and the Radiation Injury Treatment Network (RITN) sponsored a two-day meeting titled Immune Dysfunction from Radiation Exposure held on September 9-10, 2020. The intent was to discuss the manifestations and mechanisms of radiation-induced immune dysfunction in people and animals, identify knowledge gaps, and discuss possible treatments to restore immune function and enhance tissue repair after irradiation.

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Figures

FIG. 1.
FIG. 1.
The danger immune response to radiation-induced cell injury and death.
See this image and copyright information in PMC

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