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Case Reports
. 2023 Nov 27;15(11):e49510.
doi: 10.7759/cureus.49510. eCollection 2023 Nov.

Primary Gastric Leiomyosarcoma: A Rare Case

Tengfei Wang  1 , Riyam Zreik  1 , Bing Leng  1
Affiliations
Case Reports

Primary Gastric Leiomyosarcoma: A Rare Case

Tengfei Wang et al. Cureus. .

Abstract

Gastric leiomyosarcoma is extremely rare. In this paper, we present a case of primary gastric leiomyosarcoma located in the fundus/cardia region. The tumoral spindle cells show diffusely moderate nuclear atypia, with focally marked atypia and rare mitotic figures. Additionally, the tumoral cells exhibit positive immunoreactivity to smooth muscle actin and desmin while testing negative for CD117 (c-kit). The tumor was successfully resected through a laparoscopic partial gastrectomy, and the patient experienced a full recovery. There has been no recurrence or metastatic tumor detection during the seven-year follow-up period. Furthermore, we conducted a literature review on primary gastric leiomyosarcoma.

Keywords: gastrointestinal stromal tumor (gist); helicobacter pylori; leiomyosarcoma; low-grade; stomach.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Mass in the gastric fundus/cardia region.
(A) A submucosal lesion was revealed in EGD; (B) CT scan indicated an ovoid intraluminal mass. blue arrow: mass, approximately 3.0 cm × 2.3 cm; (C) the gross appearance of gastric leiomyosarcoma.
Figure 2
Figure 2. Microscopic appearance of gastric leiomyosarcoma.
Intersecting fascicles of spindle tumoral cells (A, H&E, 40×) with abundant eosinophilic cytoplasm and cytologic atypia (B, H&E, 400×).
Figure 3
Figure 3. Histology and immunostains of the primary gastric leiomyosarcoma.
A mitotic figure (A, H&E, arrowhead), tumor cells were positive for SMA (B) and desmin (C) but negative for CD117 (D). Scale bar: 20 µm.
See this image and copyright information in PMC

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