Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Nov 27;15(11):e49510.
doi: 10.7759/cureus.49510. eCollection 2023 Nov.

Primary Gastric Leiomyosarcoma: A Rare Case

Tengfei Wang  1 , Riyam Zreik  1 , Bing Leng  1
Affiliations
Case Reports

Primary Gastric Leiomyosarcoma: A Rare Case

Tengfei Wang et al. Cureus. .

Abstract

Gastric leiomyosarcoma is extremely rare. In this paper, we present a case of primary gastric leiomyosarcoma located in the fundus/cardia region. The tumoral spindle cells show diffusely moderate nuclear atypia, with focally marked atypia and rare mitotic figures. Additionally, the tumoral cells exhibit positive immunoreactivity to smooth muscle actin and desmin while testing negative for CD117 (c-kit). The tumor was successfully resected through a laparoscopic partial gastrectomy, and the patient experienced a full recovery. There has been no recurrence or metastatic tumor detection during the seven-year follow-up period. Furthermore, we conducted a literature review on primary gastric leiomyosarcoma.

Keywords: gastrointestinal stromal tumor (gist); helicobacter pylori; leiomyosarcoma; low-grade; stomach.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Mass in the gastric fundus/cardia region.
(A) A submucosal lesion was revealed in EGD; (B) CT scan indicated an ovoid intraluminal mass. blue arrow: mass, approximately 3.0 cm × 2.3 cm; (C) the gross appearance of gastric leiomyosarcoma.
Figure 2
Figure 2. Microscopic appearance of gastric leiomyosarcoma.
Intersecting fascicles of spindle tumoral cells (A, H&E, 40×) with abundant eosinophilic cytoplasm and cytologic atypia (B, H&E, 400×).
Figure 3
Figure 3. Histology and immunostains of the primary gastric leiomyosarcoma.
A mitotic figure (A, H&E, arrowhead), tumor cells were positive for SMA (B) and desmin (C) but negative for CD117 (D). Scale bar: 20 µm.
See this image and copyright information in PMC

References

    1. Leiomyosarcoma of the stomach: a case report. Kang WZ, Xue LY, Tian YT. World J Clin Cases. 2019;7:3575–3582. - PMC - PubMed
    1. Primary leiomyosarcomas of the gastrointestinal tract in the post-gastrointestinal stromal tumor era. Aggarwal G, Sharma S, Zheng M, et al. Ann Diagn Pathol. 2012;16:532–540. - PubMed
    1. Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours. Yamamoto H, Handa M, Tobo T, et al. Histopathology. 2013;63:194–207. - PubMed
    1. Overview of Helicobacter pylori Infection: clinical features, treatment, and nutritional aspects. Öztekin M, Yılmaz B, Ağagündüz D, Capasso R. Diseases. 2021;9 - PMC - PubMed
    1. Laparoscopic and endoscopic cooperative surgery for leiomyosarcoma of the stomach: a case report with a review of the literature. Takagi T, Saito S, Yokota S, et al. Surg Case Rep. 2021;7:146. - PMC - PubMed

Publication types

LinkOut - more resources