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Review
. 2024 Sep;202(9):4158-4169.
doi: 10.1007/s12011-023-03999-0. Epub 2023 Dec 29.

Signal Transduction Associated with Mn-induced Neurological Dysfunction

Xiao-Wei Zheng #  1   2 , Yuan-Yuan Fang #  1   2 , Jun-Jie Lin #  1   2 , Jing-Jing Luo  1   2 , Shao-Jun Li  3   4 , Michael Aschner  5 , Yue-Ming Jiang  6   7
Affiliations
Review

Signal Transduction Associated with Mn-induced Neurological Dysfunction

Xiao-Wei Zheng et al. Biol Trace Elem Res. 2024 Sep.

Abstract

Manganese (Mn) is a heavy metal that occurs widely in nature and has a vital physiological role in growth and development. However, excessive exposure to Mn can cause neurological damage, especially cognitive dysfunction, such as learning disability and memory loss. Numerous studies on the mechanisms of Mn-induced nervous system damage found that this metal targets a variety of metabolic pathways, for example, endoplasmic reticulum stress, apoptosis, neuroinflammation, cellular signaling pathway changes, and neurotransmitter metabolism interference. This article reviews the latest research progress on multiple signaling pathways related to Mn-induced neurological dysfunction.

Keywords: Apoptosis; Autophagy; Manganese; Mitochondrial damage; Mn-induced neurological; Neuroinflammation.

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