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. 2023 Nov;85(4):668-681.
doi: 10.18999/nagjms.85.4.668.

Characteristics of adverse drug reactions due to nonsteroidal anti-inflammatory drugs: a cross-sectional study

Cholticha Sonsupap  1   2 , Pattreya Pokhakul  2 , Tetsuyoshi Kariya  1 , Yunosuke Suzuki  1 , Nobuyuki Hamajima  1 , Eiko Yamamoto  1
Affiliations

Characteristics of adverse drug reactions due to nonsteroidal anti-inflammatory drugs: a cross-sectional study

Cholticha Sonsupap et al. Nagoya J Med Sci. 2023 Nov.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for treating pain and inflammation. Spontaneous adverse drug reaction (ADR) reports represent a rich data source for the detection of unknown and rare ADRs. This cross-sectional study aimed to analyze the characteristics of ADRs due to NSAIDs in Thailand. All ADR reports of NSAIDs for systemic use from 2015 to 2019 were extracted from the national database in Thailand. Patient characteristics, drug use information, adverse event information, and source of senders in 32,857 reports were analyzed. The annual number of ADR reports due to NSAIDs decreased from 7,008 in 2015 to 5,922 in 2019. The most frequently reported drug was ibuprofen (n=12,645, 38.5%) followed by diclofenac (n=7,795, 23.7%), most patients were 40-59 years old, and the major adverse reaction was angioedema (n=7,513, 22.9%). Serious reactions were recorded in 20.7% (n=6,801) of the total ADRs. Most patients (n=20,593, 62.7%) recovered without sequelae, but there were 5,420 patients (16.5%) who could not recover and 3,109 patients (9.5%) who were recovering. Eight patients (0.02%) died of Stevens-Johnson syndrome (n=3), toxic epidermal necrolysis (n=4), and anaphylactic shock (n=1), which were possibly related to ADRs. The number of ADR reports due to NSAIDs decreased from 2015 to 2019 in Thailand. Serious ADRs and death cases accounted for 20.7% and 0.02%, respectively. Most fatal cases exhibited severe drug-induced skin reactions.

Keywords: Thailand; adverse drug reaction; nonsteroidal anti-inflammatory drug.

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Conflict of interest statement

The authors have no conflicts of interest to declare that are relevant to the content of this article.

Figures

Fig. 1
Fig. 1
The trend of reporting all adverse drug reactions and adverse drug reactions due to non-steroidal anti-inflammatory drugs from 2015 to 2019 NSAID: non-steroidal anti-inflammatory drug ADR: adverse drug reaction
Fig. 2
Fig. 2
The number of adverse drug reactions according to types of non-steroidal anti-inflammatory drugs and seriousness from 2015 to 2019 ADR: adverse drug reaction NA: not available
See this image and copyright information in PMC

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