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. 2023 Dec 27;15(4):e12518.
doi: 10.1002/dad2.12518. eCollection 2023 Oct-Dec.

Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans

Mohammad Housini  1   2 , Zhengyang Zhou  3   4 , John Gutierrez  5 , Sumedha Rao  2 , Rodwan Jomaa  2 , Kumudu Subasinghe  6 , Danielle Marie Reid  6 , Talisa Silzer  6 , Nicole Phillips  4   6 , Sid O'Bryant  2   4 , Robert Clinton Barber  2   4 ; HABS‐HD Study Team
Affiliations

Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans

Mohammad Housini et al. Alzheimers Dement (Amst). .

Abstract

INTRODUCTION: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk alleles for late-onset AD in Mexican American (MA) and non-Hispanic White (NHW) American participants enrolled in the Health and Aging Brain Study-Health Disparities Study cohort. METHODS: Using DNA extracted from this community-based diverse population, we calculated the genotype frequencies in each population to determine whether a significant difference is detected between the different ethnicities. DNA genotyping was performed per manufacturers' protocols. RESULTS: Allele and genotype frequencies for 9 of the 11 single nucleotide polymorphisms (two apolipoprotein E variants, CR1, BIN1, DRB1, NYAP1, PTK2B, FERMT2, and ABCA7) differed significantly between MAs and NHWs. DISCUSSION: The significant differences in frequencies of top AD risk alleles observed here across MAs and NHWs suggest that ethnicity-specific genetic risks for AD exist. Given our results, we are advancing additional projects to further elucidate ethnicity-specific differences in AD.

Keywords: Alzheimer's disease; Hispanic; Mexican American; dementia; diversity; genetics; health disparities; mild cognitive impairment.

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Conflict of interest statement

The authors do not report any conflicts of interest relating to the work in this article. Author disclosures are available in the supporting information.

Figures

FIGURE 1
FIGURE 1
A, APOE ε4 positivity among MA and NHW participants in HABS‐HD. B, APOE ε4 variant frequencies between MA NHW participants in HABS‐HD. APOE, apolipoprotein E; HABS‐HD, Health and Aging Brain Study–Health Disparities; MA, Mexican American; NHW, non‐Hispanic White
FIGURE 2
FIGURE 2
A, SNPs with a significant genotype frequency difference between ethnicities. B, SNPs with no significant genotype frequency difference between ethnicities. SNPs, single nucleotide polymorphisms
FIGURE 3
FIGURE 3
LD heatmaps for APOE, rs9271058 (DRB1), rs4844610 (CR1), rs73223431 (PTK2B); created by Haploview. Left, Mexican Americans; Right, non‐Hispanic Whites. APOE, apolipoprotein E; LD, linkage disequilibrium
FIGURE 4
FIGURE 4
LD heatmaps for rs3752246 (ABCA7), rs6733839 (BIN1), rs9473117 (CD2AP), rs17125924 (FERMT2); created by Haploview. Left, Mexican Americans; Right, non‐Hispanic Whites. LD, linkage disequilibrium
See this image and copyright information in PMC

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