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. 2023 Dec 14:17:11790.
doi: 10.3389/or.2023.11790. eCollection 2023.

Challenges of FGFR2 Testing in Gastric Cancer

Affiliations

Challenges of FGFR2 Testing in Gastric Cancer

Ilya Tsimafeyeu et al. Oncol Rev. .
No abstract available

Keywords: amplification; expression; fibroblast growth factor receptor 2; gastric cancer; heterogeneity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Intratumor heterogeneity of FGFR2 IHC expression in the primary tumor (A,C), which led to the appearance of FGFR2-negative metastasis (B) and FGFR2-positive metastasis (D) in the same patient.

References

    1. Tsimafeyeu I, Rahib L. The Future Landscape of Cancer Incidence and Mortality Until 2036 in the Russian Federation. J Clin Oncol (2022) 40(16):e22518. 10.1200/JCO.2022.40.16_suppl.e22518 - DOI
    1. NCCN. NCCN Guidelines: Gastric Cancer, Version 2.2023 (2023).
    1. Shitara K, Lordick F, Bang YJ, Enzinger P, Ilson D, Shah MA, et al. Zolbetuximab Plus mFOLFOX6 in Patients With CLDN18.2-Positive, HER2-Negative, Untreated, Locally Advanced Unresectable or Metastatic Gastric or Gastro-Oesophageal Junction Adenocarcinoma (SPOTLIGHT): A Multicentre, Randomised, Double-Blind, Phase 3 Trial. The Lancet (2023) 401(10389):1655–68. 10.1016/S0140-6736(23)00620-7 - DOI - PubMed
    1. Katoh M. Fibroblast Growth Factor Receptors as Treatment Targets in Clinical Oncology. Nat Rev Clin Oncol (2019) 16(2):105–22. 10.1038/s41571-018-0115-y - DOI - PubMed
    1. Lengyel CG, Hussain S, Seeber A, Jamil Nidhamalddin S, Trapani D, Habeeb BS, et al. FGFR Pathway Inhibition in Gastric Cancer: The Golden Era of an Old Target? Life (Basel) (2022) 12(1):81. 10.3390/life12010081 - DOI - PMC - PubMed