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Case Reports
. 2023 Nov 28;15(11):e49548.
doi: 10.7759/cureus.49548. eCollection 2023 Nov.

Corticosteroid-Induced Myopathy

Andreia Coutinho  1 , Núria Fonseca  1 , Isabel Novo  1 , Luciana Faria  1 , Violeta Iglesias  1
Affiliations
Case Reports

Corticosteroid-Induced Myopathy

Andreia Coutinho et al. Cureus. .

Abstract

Corticosteroid-induced myopathy is the most common drug-induced myopathy and could appear during the treatment of diseases where corticosteroids are the mainstay of treatment. We present a clinical case of a patient treated with corticosteroids who presented with proximal muscle weakness, myalgias, marked elevation of muscle enzymes, and acute kidney injury due to rhabdomyolysis. The definitive diagnosis was only possible through a muscle biopsy.

Keywords: acute myopathy; corticosteroid side effects; corticosteroid-induced myopathy; muscle biopsy; toxic myopathy.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Histology Images of Muscle Biopsy
Hematoxylin and eosin staining (A) displays frequent atrophied fibers with predominantly angular contours scattered throughout the fascicles, in the absence of necrotic fibers, basophilic fibers, or inflammatory infiltrates. Immunohistochemistry for fast myosin (B) reveals that most of the atrophied fibers correspond to type 2 fibers.
See this image and copyright information in PMC

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