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. 2024 May;91(5):2089-2103.
doi: 10.1002/mrm.29987. Epub 2023 Dec 29.

Mitigating slice cross-talk in multi-slice multi-echo spin echo T2 mapping

Ekaterina A Brui  1 , Zilya Badrieva  1 , Charles-Alexis de Mayenne  2 , Stanislas Rapacchi  3 , Thomas Troalen  4 , David Bendahan  3
Affiliations

Mitigating slice cross-talk in multi-slice multi-echo spin echo T2 mapping

Ekaterina A Brui et al. Magn Reson Med. 2024 May.

Abstract

Purpose: To investigate whether a T2 inter-slice variation could occur when a multi-slice multi-echo spin echo (MESE) sequence is used for image acquisition and to propose an enhanced method for reconstructing T2 maps that can effectively address and correct these variations.

Methods: Bloch simulations were performed accounting for the direct saturation effect to evaluate magnetization changes in multi-slice 2D MESE sequence. Experimental phantom scans were performed to validate these simulations. An improved version of the dictionary-based reconstruction approach was proposed, enabling the creation of a multi-slice dictionary of echo modulation curves (EMC). The corresponding method has been assayed considering inter-slice T2 variation with phantoms and in lower leg.

Results: Experimental and numerical study illustrate that direct saturation leads to a bias of EMCs. This bias during the T2 maps reconstructions using original single-slice EMC-dictionary method led to inter-slice T2 variation of 2.03% in average coefficient of variation (CV) in agarose phantoms, and up to 2.8% in vivo (for TR = 2 s, slice gap = 0%). A reduction of CV was observed when increasing the gap up to 100% (0.36% in phantoms, and up to 1.5% in vivo) or increasing TR up to 4 s (0.76% in phantoms, and up to 1.9% in vivo). Matching the multi-slice experimental data with multi-slice dictionaries provided a reduced CV of 0.54% in phantoms and up to 2.3% in vivo.

Conclusion: T2 values quantified from multi-slice MESE images using single-slice dictionaries are biased. A dedicated multi-slice EMC method providing the appropriate dictionaries can reduce the inter-slice T2 variation.

Keywords: T2 mapping; direct saturation effect; echo modulation curve; inter-slice T2 variation; quantitative MRI; slice cross-talk.

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References

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