Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec 1;24(12):4253-4261.
doi: 10.31557/APJCP.2023.24.12.4253.

Suppressor of Cytokine Signaling-3 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients in Egypt

Amal El Sharnoby  1 , Hanan M Bedair  1 , Gamal Yousef S Raia  1 , Nermeen Hamed  2 , Aliaa Sabry  3 , Fatma A Khalaf  4 , Mohamed Rashed Abd Elhamed  5 , Mohamed Abdel-Samiee  3
Affiliations

Suppressor of Cytokine Signaling-3 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients in Egypt

Amal El Sharnoby et al. Asian Pac J Cancer Prev. .

Abstract

Background: Hepatocellular carcinoma (HCC) contributes significantly to cancer mortalities worldwide. The association between a specific single nucleotide polymorphism (SNP) located within the SOCS3 gene as well as the likelihood of hepatocellular carcinoma (HCC) progression in individuals with chronic hepatitis C virus (CHC) was found to be significant. We aimed to study SOCS3 gene polymorphisms at rs4969168 and rs4969170and HCC susceptibility in individuals with CHC.

Methods: The current prospective study involved 111 subjects divided in to three groups (HCC, HCV with and with no cirrhosis, and apparently healthy individuals). Tumor staging was done using BCLC staging system. SOCS3 (rs4969168 and rs4969170) gene polymorphisms' analysis was done utilizing real-time polymerase chain reaction (RT-PCR) (via DNA extracted from all subjects). All subjects underwent a complete history, medical examination, and laboratory and radiological data collection.

Results: Compared to healthy controls, homozygous AA genotypes and heterozygous GA genotypes were substantially overrepresented in HCC patients as well as those with CHCaccompanied by cirrhosis.AFP, smoking, glucose level, and AA genotype of rs4969170 might be critical significant parameters for HCC development.

Conclusion: SOCS3 gene polymorphisms at rs4969168 and rs4969170 are associated with HCC and liver fibrosis progression in the Egyptian population with CHC infection.

Keywords: Hepatitis C Virus; Hepatocellular carcinoma; Real-Time Polymerase Chain Reaction; SOCS3 Gene Polymorphisms; cytokine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A Graphical Representation of the Fluorescence Intensity Plotted Against the Cycle Number
See this image and copyright information in PMC

References

    1. Aslam R, Raza SM, Naeemi H, et al. SOCS3 mRNA expression and polymorphisms as pretreatment predictor of response to HCV genotype 3a IFN-based treatment. SpringerPlus. 2016;5:1–9. - PMC - PubMed
    1. Azim H A, Omar A, Atef H, et al. Sorafenib plus tegafur-uracil (UFT) versus sorafenib as first line systemic treatment for patients with advanced stage HCC: a Phase II trial (ESLC01 study) J Hepatocell Carcinoma. 2018;5:109–19. - PMC - PubMed
    1. Babon JJ, Nicola NA. The biology and mechanism of action of suppressor of cytokine signaling 3. Growth Factors. 2012;30:207–19. - PMC - PubMed
    1. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53:1020–2. - PMC - PubMed
    1. Budhu A, Wang XW. The role of cytokines in hepatocellular carcinoma. J Leukoc Biol. 2006;80:1197–213. - PubMed