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. 2024 Jul;310(1):203-211.
doi: 10.1007/s00404-023-07321-0. Epub 2023 Dec 29.

Associations between maternal syphilis infection during pregnancy and low birth weight and preterm birth: a prospective cohort study

Mengting Sun  1 , Manjun Luo  1 , Tingting Wang  1   2 , Taowei Zhong  1 , Qian Chen  1 , Hanjun Liu  1 , Jiapeng Tang  1 , Liuxuan Li  1 , Jiabi Qin  3   4   5
Affiliations

Associations between maternal syphilis infection during pregnancy and low birth weight and preterm birth: a prospective cohort study

Mengting Sun et al. Arch Gynecol Obstet. 2024 Jul.

Abstract

Background: In recent years, syphilis is still the most common sexually transmitted disease worldwide. Pregnant women infected with syphilis can transmit it to the fetus in utero through mother-to-child transmission, which can directly lead to adverse pregnancy outcomes. The aim of this study was to investigate the associations between maternal syphilis infection and low birth weight and preterm birth in offspring.

Methods: Multinomial logistic regression model was used to analyze the associations between maternal syphilis infection and low birth weight and preterm birth, and to explore its stability through subgroup analysis.

Results: A total of 34,074 subjects were included in the study. After adjusting for potential confounders, maternal syphilis infection during pregnancy was associated with a 2.60-fold (95% CI 1.83-3.69) increased risk of low birth weight and a 1.91-fold (95% CI 1.35-2.69) increased risk of preterm birth. Subgroup analysis showed that the association was stable.

Conclusion: We found that maternal syphilis infection during pregnancy was significantly associated with an increased risk of low birth weight and preterm birth. The implementation of reasonable syphilis screening and standardized treatment and follow-up of pregnant syphilis may have important practical significance in reducing the low birth weight and preterm birth rate in offspring.

Keywords: Inflammation; Low birth weight; Pregnancy; Preterm birth; Syphilis infection.

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