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. 2023 Dec 29;409(1):22.
doi: 10.1007/s00423-023-03204-9.

Risk factors that impact long-term outcomes in sigmoid colon cancer with urinary bladder involvement

Vladimir Balaban  1 , Igor Sedakov  2   3 , Nikolay Bondarenko  2   3 , Stanislav Zolotukhin  2   3 , Mingze He  4 , Petr Tsarkov  5
Affiliations

Risk factors that impact long-term outcomes in sigmoid colon cancer with urinary bladder involvement

Vladimir Balaban et al. Langenbecks Arch Surg. .

Abstract

Purpose: This study aimed to identify the risk factors impacting long-term outcomes in patients diagnosed with sigmoid colon cancer with urinary bladder involvement.

Methods: A comprehensive analysis was conducted on a retrospective cohort of 118 patients who underwent multivisceral resection for sigmoid colon cancer with urinary bladder involvement between June 2002 and May 2017. Univariate and multivariate analyses were employed to identify risk factors associated with long-term outcomes.

Results: Among the included patients, 10 (8.5%) experienced grade III-IV complications according to Clavien-Dindo classification, with 4 (3.4%) presenting anastomotic leaks. The postoperative mortality was 0.8%. R0 resection was achieved in 108 (91.6%) patients. Adjuvant chemotherapy was administrated to only 31 patient (26.3%). Local recurrence was observed in 8 (6.8%) cases. Risk factors for local recurrence-free survival and disease-free survival were CCI>3, grade III-IV postoperative complications according to Clavien-Dindo classification, positive resection margins, stage III of the disease, additional resected organs (excluding colon and bladder) and the absence of adjuvant chemotherapy. The same risk factors, with the exception of CCI, were associated with overall survival.

Conclusion: This study highlights that negative resection margins, a postoperative period without grade III-IV complications, and the implementation of adjuvant chemotherapy are crucial factors contributing to improve overall, disease-free and local recurrence-free survival in patients with sigmoid colon cancer with urinary bladder involvement.

Keywords: Long-term outcomes; Multivisceral resection; Risk factors; Sigmoid colon cancer; Urinary bladder invasion.

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References

    1. Yeung TM, Stocchi L, Mortensen NJ (2013) Chapter 139 - Anatomy and Embryology of the Colon. In: Yeo CJ (ed) Shackelford's Surgery of the Alimentary Tract, Seventh edn. W.B. Saunders, Philadelphia, pp 1680–1702. https://doi.org/10.1016/B978-1-4377-2206-2.00139-1 - DOI
    1. Kondo A, Sasaki T, Kitaguchi D, Tsukada Y, Nishizawa Y, Ito M (2019) Resection of the urinary bladder for locally advanced colorectal cancer: a retrospective comparison of partial versus total cystectomy. BMC Surg 19(1):63. https://doi.org/10.1186/s12893-019-0522-8 - DOI - PubMed - PMC
    1. Kobayashi T, Kamoto T, Sugino Y, Takeuchi H, Habuchi T, Ogawa O (2003) High incidence of urinary bladder involvement in carcinomas of the sigmoid and rectum: a retrospective review of 580 patients with colorectal carcinoma. J Surg Oncol 84(4):209–214. https://doi.org/10.1002/jso.10322 - DOI - PubMed
    1. Chaleoykitti B (2005) Preoperative diagnosis of urinary bladder involvement in adenocarcinoma of colon and rectum. J Med Assoc Thai 88(12):1816–1820 - PubMed
    1. Mukai T, Nagasaki T, Akiyoshi T, Fukunaga Y, Yamaguchi T, Konishi T et al (2020) Laparoscopic multivisceral resection for locally advanced colon cancer: a single-center analysis of short- and long-term outcomes. Surg Today 50(9):1024–1031. https://doi.org/10.1007/s00595-020-01986-9 - DOI - PubMed

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