Wake, NREM, and REM sleep measures predict incident dementia

Thomas C Neylan^{1

2

3}, Christine M Walsh³

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
² Mental Health Service, Veterans Affairs Medical Center, San Francisco, CA, USA.
³ Department of Neurology, University of California, San Francisco, CA, USA.

Editorial

Thomas C Neylan et al. Sleep. 2024.

. 2024 Mar 11;47(3):zsad329.

doi: 10.1093/sleep/zsad329.

Thomas C Neylan^{1

2

3}, Christine M Walsh³

¹ Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
² Mental Health Service, Veterans Affairs Medical Center, San Francisco, CA, USA.
³ Department of Neurology, University of California, San Francisco, CA, USA.

No abstract available

Comment on

Sleep features and long-term incident neurodegeneration: a polysomnographic study.
Ibrahim A, Cesari M, Heidbreder A, Defrancesco M, Brandauer E, Seppi K, Kiechl S, Högl B, Stefani A. Ibrahim A, et al. Sleep. 2024 Mar 11;47(3):zsad304. doi: 10.1093/sleep/zsad304. Sleep. 2024. PMID: 38001022 Free PMC article.

1. Mander BA, Marks SM, Vogel JW, et al. . beta-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation. Nat Neurosci. 2015;18(7):1051–1057. doi: 10.1038/nn.4035 - DOI - PMC - PubMed
1. Musiek ES, Holtzman DM.. Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science. 2016;354(6315):1004–1008. doi: 10.1126/science.aah4968 - DOI - PMC - PubMed
1. Liguori C, Romigi A, Nuccetelli M, et al. . Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease. JAMA Neurol. 2014;71(12):1498–1505. doi: 10.1001/jamaneurol.2014.2510 - DOI - PubMed
1. Kang JE, Lim MM, Bateman RJ, et al. . Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science. 2009;326(5955):1005–1007. doi: 10.1126/science.1180962 - DOI - PMC - PubMed
1. Xie L, Kang H, Xu Q, et al. . Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373–377. doi: 10.1126/science.1241224 - DOI - PMC - PubMed