Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 Apr;21(4):e14631.
doi: 10.1111/iwj.14631. Epub 2023 Dec 30.

Effect of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction: A meta-analysis

Lijun Jin  1 , Tu Ba  1
Affiliations
Meta-Analysis

Effect of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction: A meta-analysis

Lijun Jin et al. Int Wound J. 2024 Apr.

Retraction in

Abstract

The purpose of the meta-analysis was to evaluate and compare the effects of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction. The results of this meta-analysis were analysed, and the odds ratio (OR) and mean difference with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random- or fixed-effect models. For the current meta-analysis, 18 examinations spanning from 2009 to 2023 were included, encompassing 19 301 females with instant breast reconstruction. Systemic antibiotic prophylaxis had a significantly lower surgical site wound infection rate (OR, 0.85; 95% CI, 0.75-0.98, p = 0.02) compared with the standard of care after instant breast reconstruction in females. Topical antibiotic prophylaxis had a significantly lower surgical site wound infection rate (OR, 0.26; 95% CI, 0.13-0.52, p < 0.001) compared with the standard of care after instant breast reconstruction in females. The examined data revealed that systemic and topical antibiotic prophylaxis had a significantly lower surgical site wound infection rate compared with the standard of care after instant breast reconstruction in females. However, given that several examinations had a small sample size, consideration should be given to their values.

Keywords: antibiotic prophylaxis; instant breast reconstruction; standard of care; surgical site wound infection.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Schematic diagram of the examination procedure.
FIGURE 2
FIGURE 2
The effect's forest plot of the systemic antibiotics therapy compared with standard of care on wound infection rate in instant breast reconstruction in females.
FIGURE 3
FIGURE 3
The effect's forest plot of the topical antibiotics therapy compared with standard of care on graft take rate in instant breast reconstruction in females.
FIGURE 4
FIGURE 4
The funnel plot of the systemic antibiotics therapy compared with standard of care on wound infection after instant breast reconstruction in females.
FIGURE 5
FIGURE 5
The funnel plot of the topical antibiotics therapy compared with standard of care on graft take rate in instant breast reconstruction in females.
See this image and copyright information in PMC

References

    1. McPherson K, Steel C, Dixon J. ABC of breast diseases: breast cancer—epidemiology, risk factors, and genetics. BMJ. 2000;321(7261):624‐628. - PMC - PubMed
    1. Matsen CB, Neumayer LA. Breast cancer: a review for the general surgeon. JAMA Surg. 2013;148(10):971‐980. - PubMed
    1. Cardoso F, Kyriakides S, Ohno S, et al. Early breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow‐up. Ann Oncol. 2019;30(8):1194‐1220. - PubMed
    1. Hanna KR, Tilt A, Holland M, et al. Reducing infectious complications in implant based breast reconstruction: impact of early expansion and prolonged drain use. Ann Plast Surg. 2016;76:S312‐S315. - PubMed
    1. Zhong T, Hu J, Bagher S, et al. A comparison of psychological response, body image, sexuality, and quality of life between immediate and delayed autologous tissue breast reconstruction: a prospective long‐term outcome study. Plast Reconstr Surg. 2016;138(4):772‐780. - PubMed

MeSH terms

Substances