Coronavirus and the Cytoskeleton of Virus-Infected Cells

doi:10.1007/978-3-031-40086-5_12

. 2023:106:333-364.

doi: 10.1007/978-3-031-40086-5_12.

Coronavirus and the Cytoskeleton of Virus-Infected Cells

Yifan Xing^#^{1

2}, Qian Zhang^#³, Yaming Jiu^{4

5

6}

Affiliations

¹ Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
⁴ Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai, China. ymjiu@siii.cas.cn.
⁵ University of Chinese Academy of Sciences, Beijing, China. ymjiu@siii.cas.cn.
⁶ Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China. ymjiu@siii.cas.cn.

^# Contributed equally.

PMID: 38159233
DOI: 10.1007/978-3-031-40086-5_12

Coronavirus and the Cytoskeleton of Virus-Infected Cells

Yifan Xing et al. Subcell Biochem. 2023.

. 2023:106:333-364.

doi: 10.1007/978-3-031-40086-5_12.

Authors

Yifan Xing^#^{1

2}, Qian Zhang^#³, Yaming Jiu^{4

5

6}

Affiliations

¹ Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
⁴ Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai, China. ymjiu@siii.cas.cn.
⁵ University of Chinese Academy of Sciences, Beijing, China. ymjiu@siii.cas.cn.
⁶ Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China. ymjiu@siii.cas.cn.

^# Contributed equally.

PMID: 38159233
DOI: 10.1007/978-3-031-40086-5_12

Abstract

The cytoskeleton, which includes actin filaments, microtubules, and intermediate filaments, is one of the most important networks in the cell and undertakes many fundamental life activities. Among them, actin filaments are mainly responsible for maintaining cell shape and mediating cell movement, microtubules are in charge of coordinating all cargo transport within the cell, and intermediate filaments are mainly thought to guard against external mechanical pressure. In addition to this, cytoskeleton networks are also found to play an essential role in multiple viral infections. Due to the COVID-19 epidemic, including SARS-CoV-2, SARS-CoV and MERS-CoV, so many variants have caused wide public concern, that any virus infection can potentially bring great harm to human beings and society. Therefore, it is of great importance to study coronavirus infection and develop antiviral drugs and vaccines. In this chapter, we summarize in detail how the cytoskeleton responds and participates in coronavirus infection by analyzing the possibility of the cytoskeleton and its related proteins as antiviral targets, thereby providing ideas for finding more effective treatments.

Keywords: Actin; Coronavirus; Cytoskeleton; Infection; Intermediate filaments; Microtubule; SARS-CoV-2.

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[1] Amraei R et al (2022) Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc Natl Acad Sci U S A 119(6):e2113874119 - PubMed - PMC - DOI

[2] Amraei R et al (2022) Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc Natl Acad Sci U S A 119(6):e2113874119 - PubMed - PMC - DOI

[3] Andalib S et al (2021) Peripheral nervous system manifestations associated with COVID-19. Curr Neurol Neurosci Rep 21:9 - PubMed - PMC - DOI

[4] Andalib S et al (2021) Peripheral nervous system manifestations associated with COVID-19. Curr Neurol Neurosci Rep 21:9 - PubMed - PMC - DOI

[5] Bai H et al (2021) The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα. JCI Insight 6(4):e134881 - PubMed - PMC

[6] Bai H et al (2021) The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα. JCI Insight 6(4):e134881 - PubMed - PMC

[7] Basky G et al (2022) XE, XD & XF: what to know about the omicron hybrid variants. CMAJ 194:E654–e655 - PubMed - PMC - DOI

[8] Basky G et al (2022) XE, XD & XF: what to know about the omicron hybrid variants. CMAJ 194:E654–e655 - PubMed - PMC - DOI

[9] Basu R et al (2017) Microtubule-assisted altered trafficking of astrocytic gap junction protein connexin 43 is associated with depletion of connexin 47 during mouse hepatitis virus infection. J Biol Chem 292:14747–14763 - PubMed - PMC - DOI

[10] Basu R et al (2017) Microtubule-assisted altered trafficking of astrocytic gap junction protein connexin 43 is associated with depletion of connexin 47 during mouse hepatitis virus infection. J Biol Chem 292:14747–14763 - PubMed - PMC - DOI

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Coronavirus and the Cytoskeleton of Virus-Infected Cells

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Coronavirus and the Cytoskeleton of Virus-Infected Cells

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