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. 1987 Jan;12(1):73-8.
doi: 10.2165/00003088-198712010-00005.

Plasma concentrations of mianserin after single dose and at steady-state in depressed elderly patients

S Dawling, S Ford, P Ariyanayagam, H O'Neal, R R Lewis

Plasma concentrations of mianserin after single dose and at steady-state in depressed elderly patients

S Dawling et al. Clin Pharmacokinet. 1987 Jan.

Abstract

Plasma mianserin and desmethylmianserin concentrations were measured in 17 clinically depressed elderly patients after a single 30 mg dose of mianserin. The patients then received mianserin 30 mg daily for up to 6 weeks and the plasma concentrations were measured at weekly intervals. The relationship between concentrations of mianserin and desmethylmianserin at steady-state and at 16 and 24 hours after the single test dose was not good enough to be used for prediction of dosage requirements. Reasons for this finding are discussed.

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