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. 2024 Apr 26;26(16):3327-3331.
doi: 10.1021/acs.orglett.3c03877. Epub 2023 Dec 31.

Total Synthesis of the Sesquiterpene (-)-Merrillianin

Isamu Shiina  1 , Takashi Iizumi  1 , Saori Taniguchi  1 , Masuhiro Sugimoto  1 , Takahisa Shimazaki  1 , Yu-Suke Yamai  1 , Go Ogawa  1 , Tetsuro Yamada  1 , Shojiro Shinohara  1 , Yosuke Kageyama  1 , Teppei Kuboki  1 , Yuki Suwa  1 , Keita Yonekura  1 , Keiichi Ito  1 , Kiyotaka Toyoyama  1 , Satoru Tateyama  1 , Takahiro Mori  1 , Takatsugu Murata  1
Affiliations

Total Synthesis of the Sesquiterpene (-)-Merrillianin

Isamu Shiina et al. Org Lett. .

Abstract

The first total synthesis of (-)-merrillianin (1), which is a natural sesquiterpene with a tricyclic structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated. This asymmetric total synthesis enabled the absolute stereostructure determination of naturally occurring (-)-1.

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