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. 2023 Dec 28;6(1):dlad153.
doi: 10.1093/jacamr/dlad153. eCollection 2024 Feb.

Long-term carriage and evolution of VREfmLong-term carriage and evolution of vancomycin-resistant Enterococcus faecium: a genomic study on consecutive isolates

Maja Johanne Søndergaard Knudsen  1 , Jose Alfredo Samaniego Castruita  1 , Sarah Mollerup  1 , Barbara Juliane Holzknecht  2   3 , Morten Hoppe  2 , Henrik Westh  1   3 , Mette Pinholt  1 , Ingrid Maria Cecilia Rubin  1
Affiliations

Long-term carriage and evolution of VREfmLong-term carriage and evolution of vancomycin-resistant Enterococcus faecium: a genomic study on consecutive isolates

Maja Johanne Søndergaard Knudsen et al. JAC Antimicrob Resist. .

Erratum in

Abstract

Objectives: To determine if vancomycin-resistant Enterococcus faecium (VREfm) carriers carry the same VREfm clone after a minimum follow-up of 365 days. For those carrying the same clone, we investigated the genomic evolution per year per genome.

Methods: We used WGS results to assign VREfm clones to each isolate and determine clone shifts. Finally, we calculated distance in core-genome MLST alleles, and the number of SNPs between consecutive VREfm isolates from patients carrying the same VREfm clone.

Results: In total, 44.2% of patients carried the same VREfm clone, and the genomic evolution was 1.8 alleles and 2.6 SNPs per genome per year.

Conclusions: In our population of long-term carriers, we calculated a molecular clock of 2.6 SNPs.

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