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. 2023 Sep-Oct;16(5):698-706.
doi: 10.5005/jp-journals-10005-2693.

Arginine: A New Paradigm in Preventive Oral Care

Varinder Goyal  1 , Satyawan Damle  2 , Manjunath P Puranik  3 , Sivakumar Nuvvula  4 , Madhu Kakanur  5 , Nikhil Marwah  6 , Sharath Asokan  7 , Baranya S Suprabha  8 , Prathima Sreenivasan  9 , Umesh Wadgave  10 , S Shyam  11 , Dewakshi Thakur  1
Affiliations

Arginine: A New Paradigm in Preventive Oral Care

Varinder Goyal et al. Int J Clin Pediatr Dent. 2023 Sep-Oct.

Abstract

Dental caries is ubiquitous and one of the most prevalent oral diseases and the foremost cause of dental pain and poor quality of life (QoL). Fluoride is an effective caries preventive agent; however, despite its use, there remain some gaps in prevention of dental caries. Arginine, an amino acid, helps to maintain a noncariogenic plaque. It shows synergistic effects with fluoride in dental caries and can help nourish the tooth by enhancing the remineralization effect of fluoride. Supplementing fluoride dentifrices with arginine can bridge the gap in caries prevention. Several clinical studies with 1.5% arginine + fluoride provide evidence for its use in prevention of dental caries. This report throws light on the benefits of arginine in dental caries and guides on its use with fluoride. Recommendations given in the report will help in effective prevention of dental caries.

How to cite this article: Goyal V, Damle S, Puranik MP, et al. Arginine: A New Paradigm in Preventive Oral Care. Int J Clin Pediatr Dent 2023;16(5):698-706.

Keywords: Arginine; Dental caries; Fluoride.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Fig. 1
Fig. 1
Low pH leads to demineralization and dental caries
Figs 2A and B
Figs 2A and B
Schematic illustration of the caries balance in (A) Health and (B) Disease
Fig. 3
Fig. 3
Risk factors associated with development of dental caries; PUFA, polyunsaturated fatty acids
Fig. 4
Fig. 4
Summary of alkali-generating pathways in the oral cavity
See this image and copyright information in PMC

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