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Case Reports
. 2023 Dec 28;2023(12):rjad684.
doi: 10.1093/jscr/rjad684. eCollection 2023 Dec.

Primary perianal Paget's disease: three cases

Erika Lydrup  1 , Marie-Louise Lydrup  2 , Erik Agger  2
Affiliations
Case Reports

Primary perianal Paget's disease: three cases

Erika Lydrup et al. J Surg Case Rep. .

Abstract

Perianal Paget's disease (PPD) is a rare intraepidermal neoplastic disease, presenting with nonspecific symptoms, such as pruritis ani or eczema. Perianal Paget's disease may present as a primary lesion or as a paramalignant phenomenon. Uniform evidence-based treatment strategies have not been defined for this rare condition, and currently, different treatment methods are suggested. This case report presents three cases of perianal Paget's disease with three different treatments and outcomes. Pathogenesis, treatment, and the importance of a strict follow-up program are discussed.

Keywords: Paget’s disease; extramammary Paget’s disease; perianal Paget’s disease.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Photograph of the affected lesion in our first patient. Mapping biopsies confirms Paget’s disease in macroscopically normal tissue.
Figure 2
Figure 2
Photograph of the lesion in our second patient. Biopsies confirming Paget’s disease in biopsy marked 1 and Paget with underlying anal gland carcinoma in biopsy marked 2.
Figure 3
Figure 3
Photograph of the area with severe perianal dermatitis in our third patient. Biopsies show primary EMPD with invasion.
See this image and copyright information in PMC

References

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