Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;20(12):1177-1184.
doi: 10.30773/pi.2023.0138. Epub 2023 Dec 18.

Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition

In Hyeok Choi  1 , Sheng-Min Wang  2 , Yoo Hyun Um  3 , Hyun Kook Lim  2 , Chang Uk Lee  1 , Dong Woo Kang  1
Affiliations

Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition

In Hyeok Choi et al. Psychiatry Investig. 2023 Dec.

Abstract

Objective: We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition.

Methods: MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F]flutemetamol, and bioelectrical impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network.

Results: There was a significant interaction of APOE ε4 carrier status with body fat mass index, visceral fat area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements in the APOE ε4 carrier with lower DMN-CEN FC.

Conclusion: The present results highlight the detrimental effect of APOE ε4 carrier status on the associations between the fat-related body composition measurements and FC in the MCI patients with Aβ accumulation.

Keywords: Apolipoprotein; Bioelectrical impedance; Body composition; Functional neuroimaging; Mild cognitive impairment.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

Yoo Hyun Um and Hyun Kook Lim, a contributing editor of the Psychiatry Investigation, were not involved in the editorial evaluation or decision to publish this article. All remaining authors have declared no conflicts of interest.

Figures

Figure 1.
Figure 1.
A significant interaction between body composition measurement and APOE ε4 carrier status for inter-network functional connectivity between DMN and CEN in mild cognitive impairment patients with positive Aβ retention. A: Body fat mass index. B: Visceral fat area. C: Ratio of waist circumference to hip circumference. FC, functional connectivity; DMN, default mode network; CEN, central executive network; APOE, apolipoprotein E; Aβ, amyloid-beta.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Jack CR, Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14:535–562. - PMC - PubMed
    1. Menon V. Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn Sci. 2011;15:483–506. - PubMed
    1. Hutchison RM, Womelsdorf T, Allen EA, Bandettini PA, Calhoun VD, Corbetta M, et al. Dynamic functional connectivity: promise, issues, and interpretations. Neuroimage. 2013;80:360–378. - PMC - PubMed
    1. Brier MR, Thomas JB, Snyder AZ, Benzinger TL, Zhang D, Raichle ME, et al. Loss of intranetwork and internetwork resting state functional connections with Alzheimer’s disease progression. J Neurosci. 2012;32:8890–8899. - PMC - PubMed
    1. Eyler LT, Elman JA, Hatton SN, Gough S, Mischel AK, Hagler DJ, et al. Resting state abnormalities of the default mode network in mild cognitive impairment: a systematic review and meta-analysis. J Alzheimers Dis. 2019;70:107–120. - PMC - PubMed

LinkOut - more resources