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Case Reports
. 2023 Dec 30;2023(12):rjad701.
doi: 10.1093/jscr/rjad701. eCollection 2023 Dec.

Granular cell tumor of the brain: case report and review of literature

Shyam Duvuru  1   2 , Vivek Sanker  2   3 , Deepak Pandit  2   4 , Sheezah Khan  2   4 , Sara Alebrahim  2   5 , Tirth Dave  2   6
Affiliations
Case Reports

Granular cell tumor of the brain: case report and review of literature

Shyam Duvuru et al. J Surg Case Rep. .

Abstract

Granular cell tumors are rare tumors that develop from Schwann cells, which are glial cells surrounding neurons of the peripheral nervous system, which serve in the process of myelination. Granular cell tumors are rarely associated with the central nervous system in humans. In this report, we analyze a patient with granular cell tumor and review the current literature.

Keywords: Schwann cells; astrocytoma; granular cell tumors; malignant giant cell.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
MRI brain with contrast—a heterogeneous irregular rim of an enhancing lesion with a size of 3.6 × 3.4 × 2.4 cm appearing in the left frontal subcortical region, with mild perilesional edema extending into the corona radiata and external capsule.
Figure 2
Figure 2
MRS showed an increased choline, reduced NAA, and prominent lipid/lactate peaks; (Ch/NAA-4.0) (Ch/Cr-1.7).
Figure 3
Figure 3
Tractography showing destruction of the left superior longitudinal fasciculus, superior occipito-frontal fasciculus, and partial destruction of the left cortical spinal tract.
Figure 4
Figure 4
The patient was positioned in the supine position, with the head fixed with a three-pin holder.
Figure 5
Figure 5
Contrast MRI depicting the tumor cavity and gross total resection.
Figure 6
Figure 6
Section study shows a poorly defined mass composed of sheets of cells separated by thin collagenous bands; cells are round to polygonal with abundant eosinophilic cytoplasm with coarse granules; cell border is distinct at places with a syncytial pattern at some area; nuclei is large and vesicular.
See this image and copyright information in PMC

References

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    1. Neelon D, Lannan F, Childs J. Granular Cell Tumor - Statpearls - NCBI Bookshelf. Granular Cell Tumor. n.d.. Retrieved February 19, 2023, from https://www.ncbi.nlm.nih.gov/books/NBK563150/. - PubMed
    1. Gunson DT. Granular Cell Tumour. DermNet. 2018. Retrieved February 19, 2023, from https://dermnetnz.org/topics/granular-cell-tumour.
    1. Vladimir O Osipov, MD . Granular Cell Tumors. Practice Essentials, Etiology and Pathophysiology, Epidemiology. 2022. Retrieved February 19, 2023, from https://emedicine.medscape.com/article/282430-overview.
    1. National Organization for Rare Disorders . Granular Cell Tumor. 2022. Retrieved February 24, 2023, from https://rarediseases.org/gard-rare-disease/granular-cell-tumor/.

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