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Review
. 2024 Jan;52(1):242-257.
doi: 10.1177/03635465231192473.

An Update on Orthobiologics: Cautious Optimism

Patrick A Nelson  1 , Tom George  2 , Edward Bowen  3 , Andrew J Sheean  4 , Asheesh Bedi  2
Affiliations
Review

An Update on Orthobiologics: Cautious Optimism

Patrick A Nelson et al. Am J Sports Med. 2024 Jan.

Abstract

Orthobiologics are rapidly growing in use given their potential to augment healing for multiple musculoskeletal conditions. Orthobiologics consist of a variety of treatments including platelet-rich plasma and stem cells that provide conceptual appeal in providing local delivery of growth factors and inflammation modulation. The lack of standardization in nomenclature and applications within the literature has led to a paucity of high-quality evidence to support their frequent use. The purpose of this review was to describe the current landscape of orthobiologics and the most recent evidence regarding their use.

Keywords: BMAC; MSC; PRP; orthobiologics; platelet-rich plasma; stem cell.

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Conflict of interest statement

One or more of the authors has declared the following potential conflict of interest or source of funding: A.J.S. has received research support from Embody Inc; support for education from Arthrex, MedInc of Texas, Mid-Atlantic Surgical Systems, and Smith + Nephew; and hospitality payments from Stryker Corporation. A.B. has received royalties and consulting fees from Arthrex; hospitality payments from GE Healthcare; speaking fees from Synthes GmbH; and consulting fees from Flexion Therapeutics. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.

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