Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Mar;32(3):280-4.
doi: 10.1007/BF01297054.

Absence of hepatic extraction of gastric inhibitory polypeptide in conscious dogs

Z Chap, T M O'Dorisio, S Cataland, J B Field

Absence of hepatic extraction of gastric inhibitory polypeptide in conscious dogs

Z Chap et al. Dig Dis Sci. 1987 Mar.

Abstract

Fractional hepatic extraction of gastric inhibitory polypeptide was examined in conscious unrestrained dogs with catheters in the portal vein, hepatic vein, and the carotid artery and Doppler flow probes on the portal vein and hepatic artery. Following a control period, endogenous gastric inhibitory polypeptide was stimulated by oral administration of glucose with and without prior infusion of atropine. In other experiments, gastric inhibitory polypeptide (20 ng/kg/min) was infused into the portal system in association with peripheral infusion of glucose. In none of these experiments was it possible to demonstrate any significant fractional hepatic extraction of gastric inhibitory polypeptide.

PubMed Disclaimer

References

    1. Am J Physiol. 1978 Jul;235(1):E88-96 - PubMed
    1. Metabolism. 1983 Jun;32(6):558-67 - PubMed
    1. Surgery. 1976 Aug;80(2):259-65 - PubMed
    1. J Clin Invest. 1985 Sep;76(3):1174-81 - PubMed
    1. Endocrinology. 1981 Aug;109(2):443-50 - PubMed

Publication types