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. 2024 Jan 2;134(1):e177383.
doi: 10.1172/JCI177383.

Building reproducible bridges to cross the "valley of death"

Timothy M Errington

Building reproducible bridges to cross the "valley of death"

Timothy M Errington. J Clin Invest. .
No abstract available

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Conflict of interest statement

Conflict of interest: The author has declared that no conflict of interest exists.

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References

    1. National Academies of Sciences, Engineering, and Medicine, eds. Reproducibility and Replicability in Science. The National Academies Press; 2019. - PubMed
    1. Sun D, et al. Why 90% of clinical drug development fails and how to improve it? Acta Pharm Sin B. 2022;12(7):3049–3062. doi: 10.1016/j.apsb.2022.02.002. - DOI - PMC - PubMed
    1. Seyhan AA. Lost in translation: the valley of death across preclinical and clinical divide — identification of problems and overcoming obstacles. Transl Med Commun. 2019;4(1):18. doi: 10.1186/s41231-019-0050-7. - DOI
    1. Perrin S. Preclinical research: Make mouse studies work. Nature. 2014;507(7493):423–425. doi: 10.1038/507423a. - DOI - PubMed
    1. Gunjur A, et al. Poor correlation between preclinical and patient efficacy data for tumor targeted monotherapies in glioblastoma: the results of a systematic review. J Neurooncol. 2022;159(9):539–549. doi: 10.1007/s11060-022-04092-7. - DOI - PubMed