Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 2;76(1):1.
doi: 10.1186/s43044-023-00430-w.

LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings

Kefaya El-Sayed  1 , Amany R Youssef  2 , Nehal M Abdel Hay  3 , Adel M Osman  4
Affiliations

LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings

Kefaya El-Sayed et al. Egypt Heart J. .

Abstract

Background: Coronary artery disease (CAD) is the main cause of death in Egypt. Many LDL-R gene locus single nucleotide polymorphisms (SNP) are found to be associated with the risk of CAD. This research aimed to assess the allelic and genotypic frequencies of rs1122608 SNP and their association with the extent of vessel affection and lipid profile in a population of Egyptians.100 CAD patients and 100 healthy controls of Egyptians were included. PCR-RFLP was used to genotype rs1122608 SNPs.

Results: Significantly higher proportion of 'T' allele among patient (risk allele). This association is of low strength (ϕ lies between 0.1 and 0.3). A participant with 'T' allele has 1.95 times higher odds to exhibit CAD versus a participant with 'G' allele. Significantly higher proportion of 'T/T' genotype among cases versus control (risk genotype). This association is of low strength (Cramer's V lies between 0.1 and 0.3). A participant with 'T/T' genotype has 4.5 times higher odds to exhibit CAD versus a participant with 'G/G'. Gensini score showed no significant association with rs1122608 genotypes (p = 0.863).

Conclusions: The mutant GT and TT genotypes and minor T allele of rs1122608 were positively correlated with CAD and considered as independent risk factors for CAD.

Keywords: CAD; Genetic polymorphism; LDL receptor; rs1122608.

PubMed Disclaimer

Conflict of interest statement

The authors have no competing interests to declare that are relevant to the content of this article.

Similar articles

See all similar articles

References

    1. Jamaldini H, Babanejad M, Mozaffari R, et al. Association of polymorphisms at LDLR locus with coronary artery disease independently from lipid profile. Acta Med Iran. 2014;52:352–359. - PubMed
    1. Aggarwal K, Seth S, Dahiya K, et al. Ischemia modified albumin in patients of cardiac and noncardiacchest pain. Biomed Res. 2011;23(1):61–65.
    1. Hassanin A, Hassanein M, Bendary A, et al. Demographics, clinical characteristics, and outcomes among hospitalized heart failure patients across different regions of Egypt. Egypt Heart J. 2020;72(1):1–9. doi: 10.1186/s43044-020-00082-0. - DOI - PMC - PubMed
    1. Ali OS, Abdelgawad HM, Mohammed MS, et al. Ischemic heart diseases in Egypt: role of xanthine oxidase system and ischemia-modified albumin. Heart Vessels. 2014;29(5):629–637. doi: 10.1056/NEJMoa054013. - DOI - PubMed
    1. WHO (2018) https://www.worldlifeexpectancy.com/egypt-coronary-heart-disease

LinkOut - more resources