Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 2;24(1):17.
doi: 10.1186/s12885-023-11616-5.

Chemotherapy-related adverse effects with anthracycline and taxane-containing regimens in patients with localized Breast cancer: a descriptive study : Mohammed VI University Hospital, Medical Oncology Department, Marrakech, Morocco

Farah Choulli  1   2 , Hassan Abdelilah Tafenzi  3   4 , Faiçal El Hattimy  5 , Mohamed Khaled Choulli  4 , Rhizlane Belbaraka  3   4
Affiliations

Chemotherapy-related adverse effects with anthracycline and taxane-containing regimens in patients with localized Breast cancer: a descriptive study : Mohammed VI University Hospital, Medical Oncology Department, Marrakech, Morocco

Farah Choulli et al. BMC Cancer. .

Abstract

Background: Although the side effects of chemotherapy are frequently described in research studies, there is little evidence on how common they are in everyday clinical care. This study's goal was to assess the most prevalent short-term side effects experienced by patients with localized breast cancer, undergoing chemotherapy based on anthracyclines and taxane-containing treatments, at the medical oncology department of the Mohammed VI University Hospital of Marrakech, Morocco.

Methods: This was a descriptive study. We conducted a listening session at the outpatient department of the hospital with the help of a structured questionnaire. The session engaged 122 women who had undergone cycles of chemotherapy. A chi-square test was used to compare the incidence and relative risk of short side effects with both anthracycline and taxane-containing regimens.

Results: The average age of participants was 49.1 years. In both regimens, the findings highlighted the frequency and relative risk of the following adverse effects: systemic symptoms (fever, asthenia and sleep disorder), gastrointestinal toxicity (Vomiting, nausea, diarrhoea, constipation, mucositis and loss of appetite), dermatological toxicity (Skin reactions on hands/feet, nail toxicity, allergies, alopecia and peripheral edema), neurological toxicity (neuropathy), arthromyalgia and ocular toxicity.

Conclusions: In conclusion, it is crucial for healthcare professionals to be conscious of the significance of these adverse effects. They must also know how to manage them. Likewise, the listening approach highlights its importance in the daily follow-up and monitoring of patients.

Keywords: Anthracycline and Taxane-containg regimens; Chemotherapy-related adverse effects; Listening approach; Localized Breast cancer; Morocco; Structured interview.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
The variations in the short-term side effects between the two regimens. When taking Anthracyclines, patients reported having more asthenia (n = 97), vomiting (n = 107), nausea (n = 101), constipation (n = 39), Mucositis (n = 70), appetite loss (n = 99), and nail color changes (n = 74). Increased allergies (n = 53), edema (n = 19), neuropathy (n = 91), Arthromyalgia (n = 76), and ocular toxicity (n = 44) were observed with the use of Taxanes
See this image and copyright information in PMC

References

    1. Global Burden of Breast Cancer | SpringerLink. https://link.springer.com/chapter/10.1007/978-1-4419-0685-4_1. Accessed 22 October 2022. - DOI
    1. Torre LA, Siegel RL, Ward EM, Jemal A. Global Cancer Incidence and Mortality Rates and Trends–An Update. Cancer Epidemiol Biomarkers Prev. 2016;25(1):16–27. doi: 10.1158/1055-9965.EPI-15-0578. - DOI - PubMed
    1. Cancer. https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed 20 October 2022.
    1. Shah SC, Kayamba V, Peek RM, Heimburger D. Cancer Control in Low- and Middle-Income countries: is it time to consider screening? J Glob Oncol. 2019;5:JGO1800200. - PMC - PubMed
    1. Registre des Cancers de la Région du Grand Casablanca. 2005–2007. https://www.contrelecancer.ma/fr/documents/registre-des-cancers-de-la-re.... Accessed 22 October 2022.