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. 2024 Jan 2;17(1):10.
doi: 10.1186/s12920-023-01769-4.

A brief comparison of polygenic risk scores and Mendelian randomisation

Victoria Garfield  1 , Emma L Anderson  2
Affiliations

A brief comparison of polygenic risk scores and Mendelian randomisation

Victoria Garfield et al. BMC Med Genomics. .

Abstract

Mendelian randomisation and polygenic risk score analysis have become increasingly popular in the last decade due to the advent of large-scale genome-wide association studies. Each approach has valuable applications, some of which are overlapping, yet there are important differences which we describe here.

Keywords: Genome-wide association studies; Horizontal pleiotropy; Mendelian randomisation; Polygenic risk scores.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Graphical representation of the conceptual similarities and differences between PRS and MR
See this image and copyright information in PMC

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