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Review
. 2024 Jan 2;17(1):1.
doi: 10.1186/s13041-023-01072-4.

Modulation of synaptic transmission through O-GlcNAcylation

Seunghyo Han #  1 , Jun-Nyeong Kim #  1 , Chan Ho Park  2 , Jin-Seok Byun  3 , Do-Yeon Kim  4 , Hyoung-Gon Ko  5
Affiliations
Review

Modulation of synaptic transmission through O-GlcNAcylation

Seunghyo Han et al. Mol Brain. .

Abstract

O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies have revealed that O-GlcNAcylation is involved in neuronal function, specifically synaptic transmission. Global alteration of the O-GlcNAc level does not affect basal synaptic transmission while the effect on synaptic plasticity is unclear. Although synaptic proteins that are O-GlcNAcylated are gradually being discovered, the mechanism of how O-GlcNAcylated synaptic protein modulate synaptic transmission has only been reported on CREB, synapsin, and GluA2 subunit of AMPAR. Future research enabling the manipulation of O-GlcNAcylation in individual synaptic proteins should reveal hidden aspects of O-GlcNAcylated synaptic proteins as modulators of synaptic transmission.

Keywords: O-GlcNAc transferase; O-GlcNAcase; O-GlcNAcylation; Synaptic plasticity; Synaptic transmission.

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Conflict of interest statement

The author(s) declares that they have no competing interests.

Figures

Fig. 1
Fig. 1
The effects of O-GlcNAcylated proteins on synaptic plasticity. O-GlcNAcylation of CREB suppresses its transcriptional activity. Synapsin is a presynaptic protein located on the synaptic vesicular membrane. Synaptic vesicles are tethered in the RRP zone by a network composed of synapsin and actin. O-GlcNacylated synapsins may facilitate synaptic vesicle movement to the RP zone. Although the exact sites are not identified, O-GlcNAcylation of the GluA2 subunit induces endocytosis of AMPAR. OGT, O-GlcNAc transferase; OGA, O-GlcNAcase; RP, reserve pool; RRP, readily releasable pool
See this image and copyright information in PMC

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