Tick-borne infections in children in North America
- PMID: 38167816
- PMCID: PMC10932821
- DOI: 10.1097/MOP.0000000000001326
Tick-borne infections in children in North America
Abstract
Purpose of review: Because both incidence and awareness of tick-borne infections is increasing, review of major infections and recent advances related to their diagnosis and management is important.
Recent findings: A new algorithm, termed modified two-tier testing, for testing for antibodies to Borrelia burgdorferi , the cause of Lyme disease, has been approved and may replace traditional two-tier testing. In addition, doxycycline is now acceptable to use for treatment of and/or prophylaxis for Lyme disease for up to 21 days in children of any age. Borrelia miyamotoi , a bacterium in the relapsing fever type of Borrelia, is the first of this type of Borrelia that is transmitted by hard-bodied ticks such as Ixodes scapularis.
Summary: Awareness of these infections and advances in their diagnosis and treatment is important to assure the best outcomes for affected patients. Table 1 contains a summary of infections discussed.
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Conflict of interest statement
Potential Conflicts of interest: Dr. Shapiro receives royalties from UptoDate and has served as an expert witness for law firms and as a consultant to Pfizer.
Similar articles
-
Human pathogens associated with the blacklegged tick Ixodes scapularis: a systematic review.Parasit Vectors. 2016 May 5;9:265. doi: 10.1186/s13071-016-1529-y. Parasit Vectors. 2016. PMID: 27151067 Free PMC article.
-
Lyme borreliosis in Brazil: a critical review on the Baggio-Yoshinari syndrome (Brazilian Lyme-like disease).Clin Microbiol Rev. 2024 Dec 10;37(4):e0009724. doi: 10.1128/cmr.00097-24. Epub 2024 Nov 4. Clin Microbiol Rev. 2024. PMID: 39494872 Review.
-
Molecular Detection and Characterization of Tick-Borne Pathogens in Ixodes ricinus Ticks Collected from Humans.Pathogens. 2025 May 25;14(6):528. doi: 10.3390/pathogens14060528. Pathogens. 2025. PMID: 40559536 Free PMC article.
-
The Accuracy of Diagnostic Tests for Lyme Disease in Humans, A Systematic Review and Meta-Analysis of North American Research.PLoS One. 2016 Dec 21;11(12):e0168613. doi: 10.1371/journal.pone.0168613. eCollection 2016. PLoS One. 2016. PMID: 28002488 Free PMC article.
-
Research effort on birds' reservoir host potential for Lyme borreliosis: A systematic review and perspectives.Transbound Emerg Dis. 2022 Sep;69(5):2512-2522. doi: 10.1111/tbed.14305. Epub 2021 Sep 21. Transbound Emerg Dis. 2022. PMID: 34453490
References
-
-
Mead P Epidemiology of Lyme Disease. Infect Dis Clin North Am. 2022;36(3):495–521.
Good review of the changing epidemiology of Lyme disease.
-
-
-
McCarthy CA, Helis JA, Daikh BE. Lyme Disease in Children. Infect Dis Clin North Am. 2022;36(3):593–603.
Review of Lyme disease including updated recommendations for treatment.
-
-
-
Kobayashi T, Auwaerter PG. Diagnostic Testing for Lyme Disease. Infect Dis Clin North Am. 2022;36(3):605–20.
Good explanation of the changes to diagnostic testing for antibodies to Lyme disease.
-
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials