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Review
. 2024 Jun;55(2):497-510.
doi: 10.1007/s12029-023-00990-9. Epub 2024 Jan 2.

Biomarker Profile of Colorectal Cancer: Current Findings and Future Perspective

Seyed Hamid Hoseini  1 , Parisa Enayati  2 , Majid Nazari  3   4 , Emad Babakhanzadeh  5 , Maryam Rastgoo  6 , Nilufar Bagherzadeh Sohrabi  7
Affiliations
Review

Biomarker Profile of Colorectal Cancer: Current Findings and Future Perspective

Seyed Hamid Hoseini et al. J Gastrointest Cancer. 2024 Jun.

Abstract

Objective: Breakthroughs in omics technology have led to a deeper understanding of the fundamental molecular changes that play a critical role in the development and progression of cancer. This review delves into the hidden molecular drivers of colorectal cancer (CRC), offering potential for clinical translation through novel biomarkers and personalized therapies.

Methods: We summarizes recent studies utilizing various omics approaches, including genomics, transcriptomics, proteomics, epigenomics, metabolomics and data integration with computational algorithms, to investigate CRC.

Results: Integrating multi-omics data in colorectal cancer research unlocks hidden biological insights, revealing new pathways and mechanisms. This powerful approach not only identifies potential biomarkers for personalized prognosis, diagnosis, and treatment, but also predicts patient response to specific therapies, while computational tools illuminate the landscape by deciphering complex datasets.

Conclusions: Future research should prioritize validating promising biomarkers and seamlessly translating them into clinical practice, ultimately propelling personalized CRC management to new heights.

Keywords: Biomarker; Colorectal cancer; Epigenomics; Genomics; Metabolomics; Proteomics.

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References

    1. Saad El Din K, Loree JM, Sayre EC, Gill S, Brown CJ, Dau H, et al. Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review. BMC Cancer. 2020;20(1):288.
    1. Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019;16(12):713–32.
    1. Zlobec I, Lugli A. Prognostic and predictive factors in colorectal cancer. Postgrad Med J. 2008;84(994):403–11.
    1. Maida M, Macaluso FS, Ianiro G, Mangiola F, Sinagra E, Hold G, et al. Screening of colorectal cancer: present and future. Expert Rev Anticancer Ther. 2017;17(12):1131–46.
    1. Schreuders EH, Ruco A, Rabeneck L, Schoen RE, Sung JJ, Young GP, et al. Colorectal cancer screening: a global overview of existing programmes. Gut. 2015;64(10):1637–49.

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