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. 1986 Nov 12;131(1):111-7.
doi: 10.1016/0014-2999(86)90523-6.

Antagonistic activity of tiotidine and ranitidine on guinea-pig and rabbit atria

C Kilpatrick, M J Hughes, K E Light, D C Serbus

Antagonistic activity of tiotidine and ranitidine on guinea-pig and rabbit atria

C Kilpatrick et al. Eur J Pharmacol. .

Abstract

Isolated, spontaneously beating atrial pairs from rabbits and guinea-pigs were used to determine and to compare the activity of ranitidine and tiotidine as antagonists of histamine stimulated chronotropic activity. Ranitidine produced a classical competitive, reversible antagonism of histamine effects with a pA2 in rabbit atria of 8.2. In contrast, tiotidine produced both a dextral shift of the log dose-response curve, as well as a previously unreported suppression in the maximal response produced by histamine. In accordance with receptor theory, this type of activity represents a dualistic antagonism of histamine chronotropic responses.

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