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. 2024 Jan 2;28(1):7.
doi: 10.1186/s13054-023-04781-3.

Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics

Rémy Coudereau  1   2 , Muzhda Haem Rahimi  1   2 , Anne-Claire Lukaszewicz  2   3 , Martin Cour  4 , Frank Bidar  3 , Laurent Argaud  4 , Fabienne Venet  1   5 , Guillaume Monneret  6   7
Affiliations

Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics

Rémy Coudereau et al. Crit Care. .
No abstract available

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Monitoring of immature neutrophils and LOX‐1 PMN‐MDSC over time in COVID-19 and septic shock patients. A Table depicting patients’ main characteristics. B Percentages of immature neutrophils (CD10lowCD16low) among total neutrophils were measured in peripheral blood from 15 healthy controls and 14 COVID‐19 ICU patients (D0: n = 14; D3: n = 12; and D7: n = 6), or 17 septic shock patients (D0: n = 15; D3: n = 14; and D7: n = 6). Percentages of LOX‐1 MDSCs among total neutrophils were measured in peripheral blood from 15 healthy controls and 15 COVID‐19 ICU patients (D0: n = 15; D3: n = 13; and D7: n = 7), or 17 septic shock patients (D0: n = 14; D3: n = 13; and D7: n = 7). Nonparametric Mann–Whitney U-test was used to compare values between controls and patients (** p < 0.01 and *** p < 0.001). C Correlation of LOX‐1 MDSCs and immature neutrophils in COVID-19 patients (left panel) and septic shock patients (right panel). Correlations were calculated using Spearman correlation test. D Representative examples (D0 and D7) of LOX‐1 MDSCs (CD45lowLOX-1pos, supper panel) and immature neutrophils (CD10lowCD16low, lower panel) characterization for one COVID‐19 ICU patient (left panels) and one septic shock patient (right panels). Cells were gated on whole neutrophil population based on CD45/SSC characteristics. LOX-1 MDSCs from COVID-19 patients are coloured in orange. LOX-1 MDSCs from septic shock patients are coloured in blue
See this image and copyright information in PMC

References

    1. Hollen MK, Stortz JA, Darden D, Dirain ML, Nacionales DC, Hawkins RB, et al. Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis. Crit Care. 2019;23(1):355. doi: 10.1186/s13054-019-2628-x. - DOI - PMC - PubMed
    1. Waeckel L, Venet F, Gossez M, Monard C, Rimmele T, Monneret G. Delayed persistence of elevated monocytic MDSC associates with deleterious outcomes in septic shock: a retrospective cohort study. Crit Care. 2020;24(1):132. doi: 10.1186/s13054-020-02857-y. - DOI - PMC - PubMed
    1. Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. 2016;7:12150. doi: 10.1038/ncomms12150. - DOI - PMC - PubMed
    1. Condamine T, Dominguez GA, Youn JI, Kossenkov AV, Mony S, Alicea-Torres K, et al. Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients. Sci Immunol. 2016;1(2). - PMC - PubMed
    1. Coudereau R, Waeckel L, Cour M, Rimmele T, Pescarmona R, Fabri A, et al. Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome. J Leukoc Biol;2021. - PMC - PubMed

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