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Meta-Analysis
. 2024 Jan 1;21(2):253-264.
doi: 10.7150/ijms.86720. eCollection 2024.

Appraising and comparing the role of autogenous periosteal graft as a barrier membrane in the treatment of intrabony defects in chronic periodontitis cases: A systematic review and meta-analysis

Jui Bhandare  1 , Swapna A Mahale  1 , Saquib S Abullais  2 , Ankita Katkurwar  1 , Saad M AlQahtani  2 , Youssef A Algarni  3 , Shaik Mohammed Asif  4
Affiliations
Meta-Analysis

Appraising and comparing the role of autogenous periosteal graft as a barrier membrane in the treatment of intrabony defects in chronic periodontitis cases: A systematic review and meta-analysis

Jui Bhandare et al. Int J Med Sci. .

Abstract

Periodontal regeneration refers to procedures aimed at restitution of lost supporting tissue around the periodontally compromised tooth. Regenerative procedures very often include the use of barrier materials to encourage the growth of key surrounding tissues. The current study aimed to evaluate the effectiveness of autogenous periosteal graft as a barrier membrane for the treatment of intrabony defects in chronic periodontitis patients. A total of four data bases MEDLINE (by PubMed), Cochrane database, EBSCO, and Google Scholar were explored to identify the studies in English up to December 2022. An additional hand search of relevant journals was also done. A team of three independent reviewers screened the retrieved articles using the inclusion criteria. Randomized control trials (RCTs) evaluating the effectiveness of autogenous periosteal grafts in the treatment of intrabony defects in chronic periodontitis cases were included in the study. A total of six relevant articles were recognized for data procurement. A total of 117 patients with 68 sites with an age range between 18 years and 55 years were selected. Outcome variables examined were pocket depth (PD), clinical attachment level (CAL), radiographic bone defect fill (BDF), gingival recession (GR), plaque index (PI), gingival index (GI) and bleeding on probing (BOP). Data were analyzed using Revman 5.3 software. The mean differences and 95% confidence interval were used to illustrate the estimate of effect size. There is an equal effect in both groups for the PI, GI, and BOP reduction. For PD reduction, the result was in the favor of periosteal graft with open flap debridement (OFD) group. For CAL gain, radiographic BDF and GR, results also favored the periosteal graft, but no statistically significant difference was found amongst the groups. Within the limitation of the study, it seems that the autogenous periosteal graft can be used successfully along with OFD to treat intrabony defects in chronic periodontitis patients.

Keywords: autogenous periosteal graft; chronic periodontitis; intrabony defects; meta-analysis; systematic review.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Process of study selection described in PRISMA flow diagram.
Figure 2
Figure 2
Risk of bias of the included studies.
Figure 2A
Figure 2A
Forest plot for probing depth.
Figure 2B
Figure 2B
Forest plot for clinical attachment levels.
Figure 2C
Figure 2C
Forest plot for bone defect fill.
Figure 2D
Figure 2D
Forest plot for gingival recession.
Figure 2E
Figure 2E
Forest plot for plaque index.
Figure 2F
Figure 2F
Forest plot for gingival index.
Figure 2G
Figure 2G
Forest plot for bleeding on probing.
See this image and copyright information in PMC

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References

    1. Cho YD, Kim KH, Lee YM. et al. Periodontal wound healing and tissue regeneration: a narrative review. Pharmaceuticals. 2021;14:456. - PMC - PubMed
    1. Ramseier CA, Rasperini G, Batia S. et al. Advanced reconstructive technologies for periodontal tissue repair. Periodontol 2000. 2012;59:185–202. - PMC - PubMed
    1. Ausenda F, Rasperini G, Acunzo R. et al. New perspectives in the use of biomaterials for periodontal regeneration. Materials. 2019;12:2197. - PMC - PubMed
    1. Woo HN, Cho YJ, Tarafder S. et al. The recent advances in scaffolds for integrated periodontal regeneration. Bioact Mater. 2021;6:3328–42. - PMC - PubMed
    1. Zanatta FB, Souza FG, Pinto TM. et al. Do the clinical effects of enamel matrix derivatives in infrabony defects decrease overtime?. A systematic review and meta-analysis. Braz Dent J. 2013;24:446–55. - PubMed