Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Dec 8:11:1269736.
doi: 10.3389/fped.2023.1269736. eCollection 2023.

A bibliometric analysis of chemotherapy and pain in pediatric patients over the last decade

Hua Huang  1 , Guowei Cai  2 , Hongchun Xiang  2
Affiliations
Review

A bibliometric analysis of chemotherapy and pain in pediatric patients over the last decade

Hua Huang et al. Front Pediatr. .

Abstract

Background: Chemotherapy is an important treatment for children with cancer, and chemotherapy-induced pain is an important role in affecting patients' quality of life. In our study, bibliometric analysis was used to identify current research hotspots and future research trends of chemotherapy and pain in children over the last decade. Our findings can provide a reference for the research in the field of chemotherapy and pain in children.

Method: Publications of chemotherapy and pain in children were collected from the Web of Science Core Collection database. CiteSpace was used to analyze publication characteristics from 2013 to 2022.

Results: We identified 1,130 eligible publications in the field of chemotherapy and pain in children, with an increasing trend of publications over the last decade. In the field of chemotherapy and pain in children, the United States had the most publication with 346, followed by China with 135. The author with the most published papers was Pamela S Hinds (n = 8) from the United States. The journals that published the most papers were the Journal of pediatric hematology oncology (n = 44) and Medicine (n = 44). The Journal of Clinical Oncology was cited the most frequency (n = 422). St. Jude Children's Research Hospital had the most publication (n = 23). The specific keywords related to the field of chemotherapy and pain in children were "children", "chemotherapy", "management", "childhood cancer", "randomized controlled trial" and "efficacy". Emerging research focuses predominantly on symptomatic and supportive interventions for chemotherapy and pain in children.

Conclusion: Attention to chemotherapy and pain in children with cancer was insufficient. This bibliometric analysis showed the upward trend of chemotherapy and pain in children over the last decade. More studies are needed to improve the quality of life in children with chemotherapy-induced pain. This study may provide useful information to guide future research on chemotherapy and pain in children.

Keywords: CiteSpace; cancer; chemotherapy; children; pain.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Network of the productive countries on pediatric chemotherapy-related pain.
Figure 2
Figure 2
Network of the productive institutions.
Figure 3
Figure 3
Co-cited authors of research on chemotherapy and pain in children. (A) Map of authors network. (B) Map of co-cited authors network.
Figure 4
Figure 4
Analysis of cited journals. Work and network map of the most active cited journals in the field of pediatric chemotherapy-related pain from 2013 to 2022.
Figure 5
Figure 5
The links map and cluster map of co-cited references. (A) The links of co-cited references of chemotherapy and pain in children. (B) Top 4 references with the strongest citation bursts of chemotherapy and pain in children.
Figure 6
Figure 6
Analysis of keywords. (A) Co-occurrence graph of the keywords. (B) Analysis of keywords cluster map in chemotherapy-related pain studies. (C) The chronological order in which the keyword appears in each cluster.
Figure 7
Figure 7
The top 19 most frequently cited keywords with the strongest citation bursts.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Mohrmann C, Armer J, Hayashi RJ. Challenges evaluating chemotherapy-induced peripheral neuropathy in childhood cancer survivors. J Pediatr Oncol Nurs. (2017) 34:106–14. 10.1177/1043454216651016 - DOI - PubMed
    1. Triarico S, Romano A, Attina G, Capozza MA, Maurizi P, Mastrangelo S, et al. Vincristine-induced peripheral neuropathy (VIPN) in pediatric tumors: mechanisms, risk factors, strategies of prevention and treatment. Int J Mol Sci. (2021) 22:4112. 10.3390/ijms22084112 - DOI - PMC - PubMed
    1. Starobova H, Mueller A, Allavena R, Lohman RJ, Sweet MJ, Vetter I. Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy. Front Neurosci. (2019) 13:653. 10.3389/fnins.2019.00653 - DOI - PMC - PubMed
    1. Hathway GJ, Murphy E, Lloyd J, Greenspon C, Hulse RP. Cancer chemotherapy in early life significantly alters the maturation of pain processing. Neuroscience. (2018) 387:214–29. 10.1016/j.neuroscience.2017.11.032 - DOI - PMC - PubMed
    1. Uittenboogaard A, Neutel CLG, Ket JCF, Njuguna F, Huitema ADR, Kaspers GJL, et al. Pharmacogenomics of vincristine-induced peripheral neuropathy in children with cancer: a systematic review and meta-analysis. Cancers (Basel). (2022) 14:612. 10.3390/cancers14030612 - DOI - PMC - PubMed

LinkOut - more resources