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. 2024 Jan 15:456:122848.
doi: 10.1016/j.jns.2023.122848. Epub 2023 Dec 20.

Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage

Morenikeji A Komolafe  1 , Taofiki Sunmonu  2 , Joshua Akinyemi  3 , Fred S Sarfo  4 , Albert Akpalu  5 , Kolawole Wahab  6 , Reginald Obiako  7 , Lukman Owolabi  8 , Godwin O Osaigbovo  9 , Godwin Ogbole  10 , Hemant K Tiwari  11 , Carolyn Jenkins  12 , Daniel T Lackland  12 , Adekunle G Fakunle  13 , Ezinne Uvere  13 , Onoja Akpa  3 , Hamisu A Dambatta  8 , Josephine Akpalu  4 , Akinola Onasanya  14 , Adeniji Olaleye  6 , Okechukwu S Ogah  15 , Sulaiman Y Isah  8 , Micheal B Fawale  1 , Akintunde Adebowale  1 , Akinkunmi P Okekunle  3 , Donna Arnett  16 , Abiodun M Adeoye  15 , Atinuke M Agunloye  10 , Abiodun H Bello  6 , Adeniyi S Aderibigbe  17 , Ahmed O Idowu  1 , Ahmad A Sanusi  1 , Adebimpe Ogunmodede  1 , Simon A Balogun  18 , Adedeji A Egberongbe  2 , Folorunso T Rotimi  2 , Adeyemi Fredrick  2 , Andrew O Akinnuoye  2 , Folu A Adeniyi  2 , Benedict Calys-Tagoe  19 , Philip Adebayo  20 , Oyedunni Arulogun  13 , Obiageli U Agbogu-Ike  7 , Joseph Yaria  15 , Lambert Appiah  4 , Philip Ibinaiye  7 , Arti Singh  5 , Sunday Adeniyi  5 , Oladotun Olalusi  15 , Aliyu Mande  8 , Olayemi Balogun  7 , Rufus Akinyemi  21 , Bruce Ovbiagele  22 , Mayowa Owolabi  23 ; SIREN
Affiliations

Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage

Morenikeji A Komolafe et al. J Neurol Sci. .

Abstract

Background: Spontaneous intracerebral hemorrhage (ICH) is associated with a high case fatality rate in resource-limited settings. The independent predictors of poor outcome after ICH in sub-Saharan Africa remains to be characterized in large epidemiological studies. We aimed to determine factors associated with 30-day fatality among West African patients with ICH.

Methods: The Stroke Investigative Research and Educational Network (SIREN) study is a multicentre, case-control study conducted at 15 sites in Nigeria and Ghana. Adults aged ≥18 years with spontaneous ICH confirmed with neuroimaging. Demographic, cardiovascular risk factors, clinical features and neuroimaging markers of severity were assessed. The independent risk factors for 30-day mortality were determined using a multivariate logistic regression analysis with an adjusted odds ratio (OR) and 95% confidence interval (CI).

Results: Among 964 patients with ICH, 590 (61.2%) were males with a mean age (SD) of 54.3(13.6) years and a case fatality of 34.3%. Factors associated with 30-day mortality among ICH patients include: Elevated mean National Institute of Health Stroke Scale(mNIHSS);(OR 1.06; 95% CI 1.02-1.11), aspiration pneumonitis; (OR 7.17; 95% CI 2.82-18.24), ICH volume > 30mls; OR 2.68; 95% CI 1.02-7.00)) low consumption of leafy vegetables (OR 0.36; 95% CI 0.15-0.85).

Conclusion: This study identified risk and protective factors associated with 30-day mortality among West Africans with spontaneous ICH. These factors should be further investigated in other populations in Africa to enable the development of ICH mortality predictions models among indigenous Africans.

Keywords: Intracerebral hemorrhage; Mortality; West Africans.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that there are no conflicts of interests with the article. The article was written according to recommendation from International Committee of Medical Journals Editors.

Figures

Figure 1:
Figure 1:
Forest plot of the factors associated with 30-day mortality in ICH patients.
See this image and copyright information in PMC

References

    1. Brown DL, Morgenstern LB. Stopping the bleeding in intracerebral haemorrhage. N EnglJ Med 2005; 352 (8): 828–30 - PubMed
    1. Brown RD, Whisnant JP, Sicks JD O’ Fallon M, Wisbers DO Stroke incidence, prevalence and survival: secular trends in Rochester, Minnesota, through 1989. Stroke 1996; 27; 373–380. - PubMed
    1. Poon MT, Fonville AF, Al-Shahl SR. Long term prognosis after intracerebral haemorrhage; systematic review and meta-analysis. J NeurolNeurosurg Psychiatry, 2014; 85; 660–667 - PubMed
    1. Krish nimurthi W, Moran AF, Forouzanfar MH, Benneth DA, Mensah GA, Lawes CM et al. The global burden of haemorrhagic stroke; a summary of findings from the GBD 2010 study. Global Heart 2014; 9 (i) 101–61. - PubMed
    1. Turim S Horowitz DR, Sacher M, James H, Godblold H. Volume of ventricular blood is a determinant of outcome in supratentorial hemorrhage. Crit Care Med. 1999; 27: 617 –21 - PubMed

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