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Comment
. 2024 Jan 2;36(1):1-3.
doi: 10.1016/j.cmet.2023.12.012.

TAMC-derived creatine sustains glioblastoma growth

Huiwen Yan  1 , Pengcheng Bu  2
Affiliations
Free article
Comment

TAMC-derived creatine sustains glioblastoma growth

Huiwen Yan et al. Cell Metab. .
Free article

Abstract

Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth.
    Rashidi A, Billingham LK, Zolp A, Chia TY, Silvers C, Katz JL, Park CH, Delay S, Boland L, Geng Y, Markwell SM, Dmello C, Arrieta VA, Zilinger K, Jacob IM, Lopez-Rosas A, Hou D, Castro B, Steffens AM, McCortney K, Walshon JP, Flowers MS, Lin H, Wang H, Zhao J, Sonabend A, Zhang P, Ahmed AU, Brat DJ, Heiland DH, Lee-Chang C, Lesniak MS, Chandel NS, Miska J. Rashidi A, et al. Cell Metab. 2024 Jan 2;36(1):62-77.e8. doi: 10.1016/j.cmet.2023.11.013. Epub 2023 Dec 21. Cell Metab. 2024. PMID: 38134929 Free PMC article.

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