Unraveling the diversity and functions of tissue-resident plasma cells

Julie Tellier^{1

2}, Ilariya Tarasova^#^{3

4}, Junli Nie^#^{3

4}, Christopher S Smillie⁵, Pasquale L Fedele^{3

6

7}, Wang H J Cao^{3

4

8}, Joanna R Groom^{3

4}, Gabrielle T Belz⁸, Deepta Bhattacharya⁹, Gordon K Smyth^{3

10}, Stephen L Nutt^{11

12}

Affiliations

¹ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. tellier@wehi.edu.au.
² Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. tellier@wehi.edu.au.
³ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
⁴ Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
⁵ Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.
⁶ Haematology Department, Monash Health, Clayton, Victoria, Australia.
⁷ School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
⁸ The University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.
⁹ Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
¹⁰ School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia.
¹¹ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. nutt@wehi.edu.au.
¹² Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. nutt@wehi.edu.au.

^# Contributed equally.

PMID: 38172260
DOI: 10.1038/s41590-023-01712-w

Unraveling the diversity and functions of tissue-resident plasma cells

Julie Tellier et al. Nat Immunol. 2024 Feb.

. 2024 Feb;25(2):330-342.

doi: 10.1038/s41590-023-01712-w. Epub 2024 Jan 3.

Authors

Affiliations

¹ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. tellier@wehi.edu.au.
² Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. tellier@wehi.edu.au.
³ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
⁴ Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
⁵ Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.
⁶ Haematology Department, Monash Health, Clayton, Victoria, Australia.
⁷ School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
⁸ The University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.
⁹ Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
¹⁰ School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia.
¹¹ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. nutt@wehi.edu.au.
¹² Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. nutt@wehi.edu.au.

^# Contributed equally.

PMID: 38172260
DOI: 10.1038/s41590-023-01712-w

Abstract

Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin. This study reveals that extreme longevity is an intrinsic property of TrPCs whose transcriptome is imprinted by signals received both at the site of induction and within the tissue of residence.

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References

1. Tellier, J. & Nutt, S. L. Plasma cells: the programming of an antibody-secreting machine. Eur. J. Immunol. 49, 30–37 (2019). - PubMed - DOI
1. Shi, W. et al. Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells. Nat. Immunol. 16, 663–673 (2015). - PubMed - DOI
1. Wilson, R. P. et al. IgM plasma cells reside in healthy skin and accumulate with chronic inflammation. J. Invest. Dermatol. 139, 2477–2487 (2021). - DOI
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Unraveling the diversity and functions of tissue-resident plasma cells

Affiliations

Unraveling the diversity and functions of tissue-resident plasma cells

Authors

Affiliations

Abstract

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases