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Review
. 2024 Jan 4;6(1):1.
doi: 10.1186/s42466-023-00294-0.

Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review

Giulia Remoli #  1   2   3 , Edoardo Dalmato Schilke #  4   5 , Andrea Magi  1   2 , Antonio Ancidoni  6   3 , Giulia Negro  1   2 , Fulvio Da Re  1   2 , Maura Frigo  1   2 , Martina Giordano  7   8 , Nicola Vanacore  6   3 , Marco Canevelli  6   3 , Carlo Ferrarese  1   2 , Lucio Tremolizzo  1   2 , Ildebrando Appollonio  1   2
Affiliations
Review

Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review

Giulia Remoli et al. Neurol Res Pract. .

Abstract

Corticobasal syndrome (CBS) is a clinical syndrome determined by various underlying neurodegenerative disorders requiring a pathological assessment for a definitive diagnosis. A literature review was performed following the methodology described in the Cochrane Handbook for Systematic Reviews to investigate the additional value of traditional and cutting-edge cerebrospinal fluid (CSF) and serum/plasma biomarkers in profiling CBS. Four databases were screened applying predefined inclusion criteria: (1) recruiting patients with CBS; (2) analyzing CSF/plasma biomarkers in CBS. The review highlights the potential role of the association of fluid biomarkers in diagnostic workup of CBS, since they may contribute to a more accurate diagnosis and patient selection for future disease-modifying agent; for example, future trial designs should consider baseline CSF Neurofilament Light Chains (NfL) or progranulin dosage to stratify treatment arms according to neuropathological substrates, and serum NfL dosage might be used to monitor the evolution of CBS. In this scenario, prospective cohort studies, starting with neurological examination and neuropsychological tests, should be considered to assess the correlations of clinical profiles and various biomarkers.

Keywords: CBS biomarkers; CBS neuropathology; Corticobasal syndrome; Dementia biomarkers; Fluid biomarkers.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
A PRISMA flow diagram of the study selection process
See this image and copyright information in PMC

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