Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Dec 9:21:100250.
doi: 10.1016/j.wnsx.2023.100250. eCollection 2024 Jan.

Direct mechanical thrombectomy versus bridging therapy in acute ischemic stroke: A systematic review and meta-analysis of randomized clinical trials

María Del Carmen Cuadra-Campos  1 , Gustavo Adolfo Vásquez-Tirado  1   2 , María Del Cielo Bravo-Sotero  1
Affiliations
Review

Direct mechanical thrombectomy versus bridging therapy in acute ischemic stroke: A systematic review and meta-analysis of randomized clinical trials

María Del Carmen Cuadra-Campos et al. World Neurosurg X. .
No abstract available

Keywords: Bridging therapy; Functional independence; Intravenous thrombolysis; Ischemic stroke; Mechanical thrombectomy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Prisma flowchart of search strategy and study selection process.
Fig. 2
Fig. 2
Forest plots of efficacy compared between direct mechanical thrombectomy and bridging therapy: (a) Functional independence at 90 days (modified Rankin score ≤2); (b) Successful reperfusion in control tomography at 24–72h (Modified Arterial Occlusive Lesion ≥2); (c) Successful reperfusion according to TICI score on post-procedural angiography (eTICI 2b–3); (d) Median 90-day modified Rankin Score. dMT: Direct mechanical thrombectomy; BT: Bridging therapy; FI: Functional independence; CT: Computed tomography; Mrs: Modified Rankin Sctore; OR: Odds ratio; CI: Confidence Interval.
Fig. 3
Fig. 3
Forest plots of safety compared between direct mechanical thrombectomy and bridging therapy: (a) 90-day mortality; (b) Symptomatic intracranial hemorrhage. dMT: Direct mechanical thrombectomy; BT: Bridging therapy; sICH: Symptomatic intracranial hemorrhage; OR: Odds ratio; CI: Confidence interval.
Fig. 4
Fig. 4
Forest plot of risk difference of functional independence at 90 days (mRS ≤2) compared between direct mechanical thrombectomy and bridging therapy. dMT: Direct mechanical thrombectomy; BT: Bridging therapy; RD: Risk difference; CI: Confidence Interval.
See this image and copyright information in PMC

References

    1. Donkor E.S. Stroke in the 21st century: a snapshot of the burden, epidemiology, and quality of life. Stroke Res Treat. 2018 doi: 10.1155/2018/3238165. - DOI - PMC - PubMed
    1. Chugh C. Acute ischemic stroke: management approach. Indian J Crit Care Med Peer-Rev Off Publ Indian Soc Crit Care Med. 2019;23(Suppl 2):S140–S146. doi: 10.5005/jp-journals-10071-23192. - DOI - PMC - PubMed
    1. Herpich F., Rincon F. Management of acute ischemic stroke. Crit Care Med. 2020;48(11):1654–1663. doi: 10.1097/CCM.0000000000004597. - DOI - PMC - PubMed
    1. Hui C., Tadi P., Patti L. StatPearls Publishing; 2020. Ischemic Stroke. Treasure Island (FL) - PubMed
    1. Badhiwala J.H., Nassiri F., Alhazzani W., et al. Endovascular thrombectomy for acute ischemic stroke: a meta-analysis. JAMA. 2015;314(17):1832–1843. doi: 10.1001/jama.2015.13767. - DOI - PubMed

LinkOut - more resources