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Review
. 2024 May;172(1):1-20.
doi: 10.1111/imm.13749. Epub 2024 Jan 4.

Gut microbiota and intestinal immunity-A crosstalk in irritable bowel syndrome

Yuxuan Chen  1 , Shuyan Feng  2 , Ying Li  2 , Chi Zhang  3 , Guanqun Chao  4 , Shuo Zhang  1   5
Affiliations
Free article
Review

Gut microbiota and intestinal immunity-A crosstalk in irritable bowel syndrome

Yuxuan Chen et al. Immunology. 2024 May.
Free article

Abstract

Irritable bowel syndrome (IBS), one of the most prevalent functional gastrointestinal disorders, is characterized by recurrent abdominal pain and abnormal defecation habits, resulting in a severe healthcare burden worldwide. The pathophysiological mechanisms of IBS are multi-factorially involved, including food antigens, visceral hypersensitivity reactions, and the brain-gut axis. Numerous studies have found that gut microbiota and intestinal mucosal immunity play an important role in the development of IBS in crosstalk with multiple mechanisms. Therefore, based on existing evidence, this paper elaborates that the damage and activation of intestinal mucosal immunity and the disturbance of gut microbiota are closely related to the progression of IBS. Combined with the application prospect, it also provides references for further in-depth exploration and clinical practice.

Keywords: gut microbiota; intestinal immunity; intestinal mucosa; irritable bowel syndrome.

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References

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