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Case Reports
. 2024 Jan 4;17(1):e255646.
doi: 10.1136/bcr-2023-255646.

Paclitaxel-induced myocarditis presenting as new-onset heart failure

Devin Johnson  1 , Hillary Weisleder  2 , Haoxuan Yuan  2 , Gianni Carrozzi  2
Affiliations
Case Reports

Paclitaxel-induced myocarditis presenting as new-onset heart failure

Devin Johnson et al. BMJ Case Rep. .

Abstract

Myocarditis with systolic dysfunction is not typically associated with paclitaxel use. Here, we present a case of paclitaxel-induced myocarditis with systolic dysfunction developing after two cycles of carboplatin/paclitaxel in a woman with uterine papillary serous carcinoma and no cardiac risk factors. Myocarditis was diagnosed by cardiac MRI. The management of paclitaxel-induced myocarditis includes intravenous diuresis and initiation of heart failure with reduced ejection fraction guideline-directed medical therapy. Cessation of paclitaxel is also recommended in these patients.

Keywords: Cardiovascular system; Chemotherapy; Gynecological cancer; Heart failure; Unwanted effects / adverse reactions.

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Conflict of interest statement

Competing interests: None declared.

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