Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

Julie Sollier¹, Marek Basler¹, Petr Broz², Petra S Dittrich³, Knut Drescher¹, Adrian Egli⁴, Alexander Harms⁵, Andreas Hierlemann³, Sebastian Hiller¹, Carolyn G King⁶, John D McKinney⁷, Jacob Moran-Gilad⁸, Richard A Neher¹, Malcolm G P Page⁹, Sven Panke³, Alexandre Persat⁷, Paola Picotti¹⁰, Katharina M Rentsch¹¹, Pablo Rivera-Fuentes¹², Uwe Sauer¹⁰, Daiana Stolz^{13

14}, Sarah Tschudin-Sutter^{15

16}, Christian van Delden¹⁷, Erik van Nimwegen¹, Jan-Willem Veening¹⁸, Mattia Zampieri⁶, Annelies S Zinkernagel¹⁹, Nina Khanna^{6

15

16}, Dirk Bumann¹, Urs Jenal¹, Christoph Dehio²⁰

Affiliations

¹ Biozentrum, University of Basel, Basel, Switzerland.
² Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
³ Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
⁴ Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
⁵ Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
⁶ Department of Biomedicine, University Basel, Basel, Switzerland.
⁷ School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁸ Department of Health Policy and Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁹ Malcolm Page GmbH, Basel, Switzerland.
¹⁰ Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.
¹¹ Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
¹² Department of Chemistry, University of Zurich, Zurich, Switzerland.
¹³ Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.
¹⁴ Department of Pneumology, University Medical Center, Freiburg, Germany.
¹⁵ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
¹⁶ Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
¹⁷ University Hospitals Geneva, Geneva, Switzerland.
¹⁸ Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
¹⁹ Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
²⁰ Biozentrum, University of Basel, Basel, Switzerland. christoph.dehio@unibas.ch.

PMID: 38177300
DOI: 10.1038/s41564-023-01566-w

Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

Julie Sollier et al. Nat Microbiol. 2024 Jan.

. 2024 Jan;9(1):1-3.

doi: 10.1038/s41564-023-01566-w.

Authors

Affiliations

¹ Biozentrum, University of Basel, Basel, Switzerland.
² Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
³ Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
⁴ Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
⁵ Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
⁶ Department of Biomedicine, University Basel, Basel, Switzerland.
⁷ School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁸ Department of Health Policy and Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁹ Malcolm Page GmbH, Basel, Switzerland.
¹⁰ Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.
¹¹ Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
¹² Department of Chemistry, University of Zurich, Zurich, Switzerland.
¹³ Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.
¹⁴ Department of Pneumology, University Medical Center, Freiburg, Germany.
¹⁵ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
¹⁶ Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
¹⁷ University Hospitals Geneva, Geneva, Switzerland.
¹⁸ Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
¹⁹ Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
²⁰ Biozentrum, University of Basel, Basel, Switzerland. christoph.dehio@unibas.ch.

PMID: 38177300
DOI: 10.1038/s41564-023-01566-w

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References

1. Antimicrobial Resistance Collaborators Lancet 399, 629–655 (2022).
1. Lewis, K. Cell 181, 29–45 (2020). - DOI - PubMed
1. Luepke, K. H. et al. Pharmacotherapy 37, 71–84 (2017). - DOI - PubMed
1. Miethke, M. et al. Nat. Rev. Chem. 5, 726–749 (2021). - DOI - PubMed - PMC
1. Bjarnsholt, T. et al. Lancet Infect. Dis. 22, e88–e92 (2022). - DOI - PubMed

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Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

Affiliations

Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

Authors

Affiliations

References

MeSH terms

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LinkOut - more resources

Full Text Sources

Medical